Literature DB >> 21197572

Chemical biology of histone acetyltransferase natural compounds modulators.

Fabrizio Dal Piaz1, Antonio Vassallo, Osmany Cuesta Rubio, Sabrina Castellano, Gianluca Sbardella, Nunziatina De Tommasi.   

Abstract

Histone acetyltransferases (HATs) are a class of epigenetic enzymes crucial for chromatin restructuring and transcriptional regulation in eukaryotic cells, thus being a promising target for therapeutic development. Nonetheless, differently from histone deacetylases (HDACs) inhibitors, there is still paucity of small-molecule modulators of HAT activity. After a decline during past decade, natural products and their derivatives could be once again a valuable tool in the lead discovery process and meet such need of Novel Chemical Entities (NCEs). In this review, we will provide a comprehensive summary on the discovery of small-molecule HAT modulators from naturally occurring molecular scaffolds.

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Year:  2011        PMID： 21197572     DOI： 10.1007/s11030-010-9299-5

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  121 in total

1.  The identification of a novel natural activator of p300 histone acetyltranferase provides new insights into the modulation mechanism of this enzyme.

Authors:  Fabrizio Dal Piaz; Alessandra Tosco; Daniela Eletto; Anna L Piccinelli; Ornella Moltedo; Silvia Franceschelli; Gianluca Sbardella; Paolo Remondelli; Luca Rastrelli; Loredana Vesci; Claudio Pisano; Nunziatina De Tommasi
Journal:  Chembiochem       Date:  2010-04-12       Impact factor: 3.164

2.  Cinnamoyl compounds as simple molecules that inhibit p300 histone acetyltransferase.

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4.  The TAF(II)250 subunit of TFIID has histone acetyltransferase activity.

Authors:  C A Mizzen; X J Yang; T Kokubo; J E Brownell; A J Bannister; T Owen-Hughes; J Workman; L Wang; S L Berger; T Kouzarides; Y Nakatani; C D Allis
Journal:  Cell       Date:  1996-12-27       Impact factor: 41.582

5.  Inhibition of Nox-4 activity by plumbagin, a plant-derived bioactive naphthoquinone.

Authors:  Yaxian Ding; Zi-Jiang Chen; Shiguo Liu; Danian Che; Michael Vetter; Chung-Ho Chang
Journal:  J Pharm Pharmacol       Date:  2005-01       Impact factor: 3.765

6.  A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases.

Authors:  V M Richon; S Emiliani; E Verdin; Y Webb; R Breslow; R A Rifkind; P A Marks
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-17       Impact factor: 11.205

7.  Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation.

Authors:  Yingli Sun; Xiaofeng Jiang; Shujuan Chen; Brendan D Price
Journal:  FEBS Lett       Date:  2006-07-10       Impact factor: 4.124

8.  Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalpha kinase, leading to potentiation of apoptosis.

Authors:  Bokyung Sung; Manoj K Pandey; Kwang Seok Ahn; Tingfang Yi; Madan M Chaturvedi; Mingyao Liu; Bharat B Aggarwal
Journal:  Blood       Date:  2008-03-18       Impact factor: 22.113

9.  Inhibition of lipoxygenase and prostaglandin endoperoxide synthase by anacardic acids.

Authors:  R Grazzini; D Hesk; E Heininger; G Hildenbrandt; C C Reddy; D Cox-Foster; J Medford; R Craig; R O Mumma
Journal:  Biochem Biophys Res Commun       Date:  1991-04-30       Impact factor: 3.575

10.  Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats.

Authors:  S Sugie; K Okamoto; K M Rahman; T Tanaka; K Kawai; J Yamahara; H Mori
Journal:  Cancer Lett       Date:  1998-05-15       Impact factor: 8.679
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  9 in total

Review 1.  Phytochemical antioxidants modulate mammalian cellular epigenome: implications in health and disease.

Authors:  Smitha Malireddy; Sainath R Kotha; Jordan D Secor; Travis O Gurney; Jamie L Abbott; Gautam Maulik; Krishna R Maddipati; Narasimham L Parinandi
Journal:  Antioxid Redox Signal       Date:  2012-04-17       Impact factor: 8.401

Review 2.  Epigenetic protein families: a new frontier for drug discovery.

Authors:  Cheryl H Arrowsmith; Chas Bountra; Paul V Fish; Kevin Lee; Matthieu Schapira
Journal:  Nat Rev Drug Discov       Date:  2012-04-13       Impact factor: 84.694

3.  Epigenetic regulation of opioid-induced hyperalgesia, dependence, and tolerance in mice.

Authors:  De-Yong Liang; XiangQi Li; J David Clark
Journal:  J Pain       Date:  2013-01       Impact factor: 5.820

4.  Disubstituted naphthyl β-D-xylopyranosides: Synthesis, GAG priming, and histone acetyltransferase (HAT) inhibition.

Authors:  Karin Thorsheim; Andrea Persson; Anna Siegbahn; Emil Tykesson; Gunilla Westergren-Thorsson; Katrin Mani; Ulf Ellervik
Journal:  Glycoconj J       Date:  2016-03-29       Impact factor: 2.916

5.  Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo.

Authors:  J M Gajer; S D Furdas; A Gründer; M Gothwal; U Heinicke; K Keller; F Colland; S Fulda; H L Pahl; I Fichtner; W Sippl; M Jung
Journal:  Oncogenesis       Date:  2015-02-09       Impact factor: 7.485

6.  Histone acetyltransferase inhibitor CPTH6 preferentially targets lung cancer stem-like cells.

Authors:  Marta Di Martile; Marianna Desideri; Teresa De Luca; Chiara Gabellini; Simonetta Buglioni; Adriana Eramo; Giovanni Sette; Michele Milella; Dante Rotili; Antonello Mai; Simone Carradori; Daniela Secci; Ruggero De Maria; Donatella Del Bufalo; Daniela Trisciuoglio
Journal:  Oncotarget       Date:  2016-03-08

7.  A naturally-occurring histone acetyltransferase inhibitor derived from Garcinia indica impairs newly acquired and reactivated fear memories.

Authors:  Stephanie A Maddox; Casey S Watts; Valérie Doyère; Glenn E Schafe
Journal:  PLoS One       Date:  2013-01-21       Impact factor: 3.240

Review 8.  Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders.

Authors:  Luis M Valor; Jose Viosca; Jose P Lopez-Atalaya; Angel Barco
Journal:  Curr Pharm Des       Date:  2013       Impact factor: 3.116

Review 9.  Epigenetic control of gene function in schistosomes: a source of therapeutic targets?

Authors:  Alejandro Cabezas-Cruz; Julien Lancelot; Stéphanie Caby; Guilherme Oliveira; Raymond J Pierce
Journal:  Front Genet       Date:  2014-09-10       Impact factor: 4.599
  9 in total

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