Literature DB >> 18432331

Sub-cellular precision on-chip small-animal immobilization, multi-photon imaging and femtosecond-laser manipulation.

Fei Zeng1, Christopher B Rohde, Mehmet Fatih Yanik.   

Abstract

Techniques for stable, rapid and repeatable small-animal immobilization are necessary for high-throughput in vivo genetic/drug screens using cellular and sub-cellular features in multi-cellular organisms. We demonstrate a method for non-invasive and high-throughput on-chip immobilization of physiologically active C. elegans without the use of anesthesia or cooling, but with comparable stability even for the most demanding purposes. We show observation and manipulation of sub-cellular features in immobilized animals using two-photon microscopy and femtosecond-laser microsurgery.

Entities:  

Mesh：

Year:  2008        PMID： 18432331     DOI： 10.1039/b804808h

Source DB:  PubMed          Journal:  Lab Chip        ISSN： 1473-0189            Impact factor:   6.799


  47 in total

Review 1.  Laser microsurgery in Caenorhabditis elegans.

Authors:  Christopher Fang-Yen; Christopher V Gabel; Aravinthan D T Samuel; Cornelia I Bargmann; Leon Avery
Journal:  Methods Cell Biol       Date:  2012       Impact factor: 1.441

Review 2.  C. elegans as a genetic model to identify novel cellular and molecular mechanisms underlying nervous system regeneration.

Authors:  Hui Chiu; Amel Alqadah; Chiou-Fen Chuang; Chieh Chang
Journal:  Cell Adh Migr       Date:  2011 Sep-Oct       Impact factor: 3.405

3.  Large-scale in vivo femtosecond laser neurosurgery screen reveals small-molecule enhancer of regeneration.

Authors:  Chrysanthi Samara; Christopher B Rohde; Cody L Gilleland; Stephanie Norton; Stephen J Haggarty; Mehmet Fatih Yanik
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-11       Impact factor: 11.205

Review 4.  Investigation of nerve injury through microfluidic devices.

Authors:  Rezina Siddique; Nitish Thakor
Journal:  J R Soc Interface       Date:  2013-11-13       Impact factor: 4.118

5.  Lens-free optical tomographic microscope with a large imaging volume on a chip.

Authors:  Serhan O Isikman; Waheb Bishara; Sam Mavandadi; Frank W Yu; Steve Feng; Randy Lau; Aydogan Ozcan
Journal:  Proc Natl Acad Sci U S A       Date:  2011-04-19       Impact factor: 11.205

6.  Subcellular in vivo time-lapse imaging and optical manipulation of Caenorhabditis elegans in standard multiwell plates.

Authors:  Christopher B Rohde; Mehmet Fatih Yanik
Journal:  Nat Commun       Date:  2011       Impact factor: 14.919

Review 7.  Watching worms whither: modeling neurodegeneration in C. elegans.

Authors:  Benjamin Wolozin; Christopher Gabel; Andrew Ferree; Maria Guillily; Atsushi Ebata
Journal:  Prog Mol Biol Transl Sci       Date:  2011       Impact factor: 3.622

8.  A perspective on optical developments in microfluidic platforms for Caenorhabditis elegans research.

Authors:  Guillaume Aubry; Hang Lu
Journal:  Biomicrofluidics       Date:  2014-02-13       Impact factor: 2.800

9.  Micro-electro-fluidic grids for nematodes: a lens-less, image-sensor-less approach for on-chip tracking of nematode locomotion.

Authors:  Peng Liu; Richard J Martin; Liang Dong
Journal:  Lab Chip       Date:  2013-02-21       Impact factor: 6.799

10.  High-throughput in vivo vertebrate screening.

Authors:  Carlos Pardo-Martin; Tsung-Yao Chang; Bryan Kyo Koo; Cody L Gilleland; Steven C Wasserman; Mehmet Fatih Yanik
Journal:  Nat Methods       Date:  2010-07-18       Impact factor: 28.547
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