| Literature DB >> 18426902 |
Gregory G Stone1, Dennis Girard, Steve Finegan, Joan Duignan, John Schafer, Meghan Maloney, Richard P Zaniewski, Steven J Brickner, Sarah K Wade, Phuong T Le, Michael D Huband.
Abstract
We evaluated a novel truncated hygromycin A analog in which the furanose ring was replaced with a 2-fluoro-2-cyclopropylethyl substituent for its activity against multidrug resistant gram-positive bacteria and compared its activity to the activities of linezolid, quinupristin-dalfopristin, and vancomycin. CE-156811 demonstrated robust in vitro activity against gram-positive bacteria that was comparable to that of linezolid.Entities:
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Year: 2008 PMID： 18426902 PMCID： PMC2443909 DOI： 10.1128/AAC.01326-07
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191