Literature DB >> 18426901

Mutagenesis in the alpha3alpha4 GyrA helix and in the Toprim domain of GyrB refines the contribution of Mycobacterium tuberculosis DNA gyrase to intrinsic resistance to quinolones.

Stéphanie Matrat1, Alexandra Aubry, Claudine Mayer, Vincent Jarlier, Emmanuelle Cambau.   

Abstract

The replacement of M74 in GyrA, A83 in GyrA, and R447 in GyrB of Mycobacterium tuberculosis gyrase by their Escherichia coli homologs resulted in active enzymes as quinolone susceptible as the E. coli gyrase. This demonstrates that the primary structure of gyrase determines intrinsic quinolone resistance and was supported by a three-dimensional model of N-terminal GyrA.

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Year:  2008        PMID： 18426901      PMCID： PMC2493125          DOI： 10.1128/AAC.01380-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

Review 1.  Role of mycobacterial efflux transporters in drug resistance: an unresolved question.

Authors:  Edda De Rossi; José A Aínsa; Giovanna Riccardi
Journal:  FEMS Microbiol Rev       Date:  2006-01       Impact factor: 16.408

2.  Novel gyrase mutations in quinolone-resistant and -hypersusceptible clinical isolates of Mycobacterium tuberculosis: functional analysis of mutant enzymes.

Authors:  Alexandra Aubry; Nicolas Veziris; Emmanuelle Cambau; Chantal Truffot-Pernot; Vincent Jarlier; L Mark Fisher
Journal:  Antimicrob Agents Chemother       Date:  2006-01       Impact factor: 5.191

3.  Role of the extended alpha4 domain of Staphylococcus aureus gyrase A protein in determining low sensitivity to quinolones.

Authors:  Jacob Strahilevitz; Ari Robicsek; David C Hooper
Journal:  Antimicrob Agents Chemother       Date:  2006-02       Impact factor: 5.191

4.  Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibiotics.

Authors:  Feng Wang; Craig Cassidy; James C Sacchettini
Journal:  Antimicrob Agents Chemother       Date:  2006-08       Impact factor: 5.191

5.  Crystallography & NMR system: A new software suite for macromolecular structure determination.

Authors:  A T Brünger; P D Adams; G M Clore; W L DeLano; P Gros; R W Grosse-Kunstleve; J S Jiang; J Kuszewski; M Nilges; N S Pannu; R J Read; L M Rice; T Simonson; G L Warren
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  1998-09-01

6.  Functional analysis of DNA gyrase mutant enzymes carrying mutations at position 88 in the A subunit found in clinical strains of Mycobacterium tuberculosis resistant to fluoroquinolones.

Authors:  Stéphanie Matrat; Nicolas Veziris; Claudine Mayer; Vincent Jarlier; Chantal Truffot-Pernot; Juliette Camuset; Elisabeth Bouvet; Emmanuelle Cambau; Alexandra Aubry
Journal:  Antimicrob Agents Chemother       Date:  2006-10-02       Impact factor: 5.191

7.  Update on fluoroquinolone resistance in Helicobacter pylori: new mutations leading to resistance and first description of a gyrA polymorphism associated with hypersusceptibility.

Authors:  Vincent Cattoir; Juliette Nectoux; Christine Lascols; Lionel Deforges; Jean-Charles Delchier; Francis Megraud; Claude-James Soussy; Emmanuelle Cambau
Journal:  Int J Antimicrob Agents       Date:  2007-02-15       Impact factor: 5.283

8.  Amino acid variation in the GyrA subunit of bacteria potentially associated with natural resistance to fluoroquinolone antibiotics.

Authors:  B Waters; J Davies
Journal:  Antimicrob Agents Chemother       Date:  1997-12       Impact factor: 5.191

9.  Ancestral antibiotic resistance in Mycobacterium tuberculosis.

Authors:  Rowan P Morris; Liem Nguyen; John Gatfield; Kevin Visconti; Kien Nguyen; Dirk Schnappinger; Sabine Ehrt; Yang Liu; Leonid Heifets; Jean Pieters; Gary Schoolnik; Charles J Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-15       Impact factor: 11.205

10.  The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA).

Authors:  You-Yi Huang; Jiao-Yu Deng; Jing Gu; Zhi-Ping Zhang; Anthony Maxwell; Li-Jun Bi; Yuan-Yuan Chen; Ya-Feng Zhou; Zi-Niu Yu; Xian-En Zhang
Journal:  Nucleic Acids Res       Date:  2006-10-11       Impact factor: 16.971
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  9 in total

1.  Silver ciprofloxacin (CIPAG): a successful combination of chemically modified antibiotic in inorganic-organic hybrid.

Authors:  I Milionis; C N Banti; I Sainis; C P Raptopoulou; V Psycharis; N Kourkoumelis; S K Hadjikakou
Journal:  J Biol Inorg Chem       Date:  2018-04-13       Impact factor: 3.358

Review 2.  Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis.

Authors:  Hanna Nebenzahl-Guimaraes; Karen R Jacobson; Maha R Farhat; Megan B Murray
Journal:  J Antimicrob Chemother       Date:  2013-09-20       Impact factor: 5.790

3.  Functional Characterization of the DNA Gyrases in Fluoroquinolone-Resistant Mutants of Francisella novicida.

Authors:  Yvan Caspar; Claire Siebert; Vivien Sutera; Corinne Villers; Alexandra Aubry; Claudine Mayer; Max Maurin; Patricia Renesto
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

4.  Crystal structure and stability of gyrase-fluoroquinolone cleaved complexes from Mycobacterium tuberculosis.

Authors:  Tim R Blower; Benjamin H Williamson; Robert J Kerns; James M Berger
Journal:  Proc Natl Acad Sci U S A       Date:  2016-01-20       Impact factor: 11.205

5.  The pentapeptide repeat proteins MfpAMt and QnrB4 exhibit opposite effects on DNA gyrase catalytic reactions and on the ternary gyrase-DNA-quinolone complex.

Authors:  Audrey Mérens; Stéphanie Matrat; Alexandra Aubry; Christine Lascols; Vincent Jarlier; Claude-James Soussy; Jean-Didier Cavallo; Emmanuelle Cambau
Journal:  J Bacteriol       Date:  2008-12-05       Impact factor: 3.490

6.  Structural insights into the quinolone resistance mechanism of Mycobacterium tuberculosis DNA gyrase.

Authors:  Jérémie Piton; Stéphanie Petrella; Marc Delarue; Gwénaëlle André-Leroux; Vincent Jarlier; Alexandra Aubry; Claudine Mayer
Journal:  PLoS One       Date:  2010-08-18       Impact factor: 3.240

Review 7.  Evolution of drug resistance in tuberculosis: recent progress and implications for diagnosis and therapy.

Authors:  Andrej Trauner; Sonia Borrell; Klaus Reither; Sebastien Gagneux
Journal:  Drugs       Date:  2014-07       Impact factor: 9.546

8.  Specific gyrA gene mutations predict poor treatment outcome in MDR-TB.

Authors:  L Rigouts; N Coeck; M Gumusboga; W B de Rijk; K J M Aung; M A Hossain; K Fissette; H L Rieder; C J Meehan; B C de Jong; A Van Deun
Journal:  J Antimicrob Chemother       Date:  2015-11-24       Impact factor: 5.790

9.  Evolution of Antibiotic Resistance in Surrogates of Francisella tularensis (LVS and Francisella novicida): Effects on Biofilm Formation and Fitness.

Authors:  Fabrice V Biot; Beth A Bachert; Kevin D Mlynek; Ronald G Toothman; Galina I Koroleva; Sean P Lovett; Christopher P Klimko; Gustavo F Palacios; Christopher K Cote; Jason T Ladner; Joel A Bozue
Journal:  Front Microbiol       Date:  2020-10-30       Impact factor: 5.640
  9 in total

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