BACKGROUND: The prognostic significance of tumor location in breast cancer remains unclear. To better understand this relationship, we evaluated the Department of Defense tumor registry. METHODS: Patients with infiltrating ductal adenocarcinoma or lobular carcinoma over a 10-year period were identified and analyzed. RESULTS: Of the 13,984 tumors, 7,871 (58%) originated from the upper-outer quadrant or axillary tail, whereas the remainder were found at the nipple complex (9%), upper-inner quadrant (14%), lower-inner quadrant (9%), and lower-outer quadrant (10%). Univariate analysis of cancer-specific survival revealed a significant difference based on location of the primary breast cancer. Upper-outer quadrant lesions were associated with an independent contribution toward a survival benefit. CONCLUSIONS: Upper-outer quadrant breast cancers have a more favorable survival advantage when compared with tumors in other locations. Factors that negatively impacted survival included high-grade tumors, advanced stage, and race.
BACKGROUND: The prognostic significance of tumor location in breast cancer remains unclear. To better understand this relationship, we evaluated the Department of Defense tumor registry. METHODS:Patients with infiltrating ductal adenocarcinoma or lobular carcinoma over a 10-year period were identified and analyzed. RESULTS: Of the 13,984 tumors, 7,871 (58%) originated from the upper-outer quadrant or axillary tail, whereas the remainder were found at the nipple complex (9%), upper-inner quadrant (14%), lower-inner quadrant (9%), and lower-outer quadrant (10%). Univariate analysis of cancer-specific survival revealed a significant difference based on location of the primary breast cancer. Upper-outer quadrant lesions were associated with an independent contribution toward a survival benefit. CONCLUSIONS: Upper-outer quadrant breast cancers have a more favorable survival advantage when compared with tumors in other locations. Factors that negatively impacted survival included high-grade tumors, advanced stage, and race.
Authors: Theresa A Koleck; Catherine M Bender; Susan M Sereika; Christopher M Ryan; Puja Ghotkar; Adam M Brufsky; Rachel C Jankowitz; Priscilla F McAuliffe; Beth Z Clark; Yvette P Conley Journal: Cancer Med Date: 2017-01-13 Impact factor: 4.452
Authors: Snehal M Pinto Pereira; Valerie A McCormack; Sue M Moss; Isabel dos Santos Silva Journal: Breast Cancer Res Date: 2009-06-03 Impact factor: 6.466
Authors: Yunan Han; Justin Xavier Moore; Marvin Langston; Lindsay Fuzzell; Saira Khan; Marquita W Lewis; Graham A Colditz; Ying Liu Journal: Cancer Causes Control Date: 2019-08-27 Impact factor: 2.506