| Literature DB >> 18423606 |
John M Sedivy1, Gowrishankar Banumathy, Peter D Adams.
Abstract
Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.Entities:
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Year: 2008 PMID： 18423606 PMCID： PMC2464300 DOI： 10.1016/j.yexcr.2008.02.023
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905