Literature DB >> 18423227

Slot-blot analysis of 3-nitrotyrosine-modified brain proteins.

Rukhsana Sultana1, D Allan Butterfield.   

Abstract

3-Nitrotyrosine (3-NT) is used as a biomarker of nitrosative stress. The formation of 3-NT has been reported in a number of diseases, including Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, and cancer. The nitration of proteins is a reversible process, but it can induce a conformational change and thereby functional alterations of the affected protein. 3-NT measurements in biological samples are usually carried out by methodologies such as immunohistochemistry, high-performance liquid chromatography, gas chromatography, and immunochemical detection. This chapter describes the immunochemical method for the determination of protein-bound 3-NT using slot-blot analysis.

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Year:  2008        PMID： 18423227     DOI： 10.1016/S0076-6879(07)00820-8

Source DB:  PubMed          Journal:  Methods Enzymol        ISSN： 0076-6879            Impact factor:   1.600


  9 in total

1.  Profiles of brain oxidative damage, ventricular alterations, and neurochemical metabolites in the striatum of PINK1 knockout rats as functions of age and gender: Relevance to Parkinson disease.

Authors:  Xiaojia Ren; Angela Hinchie; Aaron Swomley; David K Powell; D Allan Butterfield
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2.  Autophagy and oxidative stress in gliomas with IDH1 mutations.

Authors:  Misty R Gilbert; Yinxing Liu; Janna Neltner; Hong Pu; Andrew Morris; Manjula Sunkara; Thomas Pittman; Natasha Kyprianou; Craig Horbinski
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Review 3.  Ubiquitin carboxyl-terminal hydrolase L-1 in brain: Focus on its oxidative/nitrosative modification and role in brains of subjects with Alzheimer disease and mild cognitive impairment.

Authors:  D Allan Butterfield
Journal:  Free Radic Biol Med       Date:  2021-11-01       Impact factor: 7.376

4.  Basal brain oxidative and nitrative stress levels are finely regulated by the interplay between superoxide dismutase 2 and p53.

Authors:  Eugenio Barone; Giovanna Cenini; Fabio Di Domenico; Teresa Noel; Chi Wang; Marzia Perluigi; Daret K St Clair; D Allan Butterfield
Journal:  J Neurosci Res       Date:  2015-08-06       Impact factor: 4.164

5.  Superoxide induces protein oxidation in plasma and TNF-α elevation in macrophage culture: Insights into mechanisms of neurotoxicity following doxorubicin chemotherapy.

Authors:  Jeriel T R Keeney; Sumitra Miriyala; Teresa Noel; Jeffrey A Moscow; Daret K St Clair; D Allan Butterfield
Journal:  Cancer Lett       Date:  2015-07-28       Impact factor: 8.679

6.  Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline.

Authors:  Jeriel T R Keeney; Sarah Förster; Rukhsana Sultana; Lawrence D Brewer; Caitlin S Latimer; Jian Cai; Jon B Klein; Nada M Porter; D Allan Butterfield
Journal:  Free Radic Biol Med       Date:  2013-07-18       Impact factor: 7.376

7.  Vitamin E is essential for Purkinje neuron integrity.

Authors:  L Ulatowski; R Parker; G Warrier; R Sultana; D A Butterfield; D Manor
Journal:  Neuroscience       Date:  2013-12-14       Impact factor: 3.590

8.  Neuroglobin-overexpression reduces traumatic brain lesion size in mice.

Authors:  Song Zhao; Zhanyang Yu; Gang Zhao; Changhong Xing; Kazuhide Hayakawa; Michael J Whalen; Josephine M Lok; Eng H Lo; Xiaoying Wang
Journal:  BMC Neurosci       Date:  2012-06-15       Impact factor: 3.288

9.  Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion.

Authors:  Tawanda Zininga; Ikechukwu Achilonu; Heinrich Hoppe; Earl Prinsloo; Heini W Dirr; Addmore Shonhai
Journal:  Cell Stress Chaperones       Date:  2016-02-19       Impact factor: 3.667
  9 in total

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