Literature DB >> 18421550

What generates flux of tubulin in kinetochore microtubules?

Arthur Forer1, Jeremy D Pickett-Heaps, Tim Spurck.   

Abstract

We discuss models for production of tubulin flux in kinetochore microtubules. Current models concentrate solely on microtubules and their associated motors and enzymes. For example, in some models the driving force for flux is enzymes at the poles and the kinetochores; in others the driving force is motor molecules that are associated with a stationary spindle matrix. We present a different viewpoint, that microtubules are propelled poleward by forces arising from the spindle matrix, that the forces on the microtubules "activate" polymerising and depolymerising enzymes at kinetochores and poles, that matrix forces utilise actin, myosin, and microtubule motors, and that the matrix itself may not necessarily be static.

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Year:  2008        PMID: 18421550     DOI: 10.1007/s00709-008-0286-y

Source DB:  PubMed          Journal:  Protoplasma        ISSN: 0033-183X            Impact factor:   3.356


  45 in total

1.  Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase.

Authors:  Gregory C Rogers; Stephen L Rogers; Tamara A Schwimmer; Stephanie C Ems-McClung; Claire E Walczak; Ronald D Vale; Jonathan M Scholey; David J Sharp
Journal:  Nature       Date:  2003-12-14       Impact factor: 49.962

2.  Spindle microtubules in flux.

Authors:  Gregory C Rogers; Stephen L Rogers; David J Sharp
Journal:  J Cell Sci       Date:  2005-03-15       Impact factor: 5.285

3.  Model of chromosome motility in Drosophila embryos: adaptation of a general mechanism for rapid mitosis.

Authors:  G Civelekoglu-Scholey; D J Sharp; A Mogilner; J M Scholey
Journal:  Biophys J       Date:  2006-03-13       Impact factor: 4.033

Review 4.  Cell and molecular biology of the spindle matrix.

Authors:  Kristen M Johansen; Jørgen Johansen
Journal:  Int Rev Cytol       Date:  2007

5.  Drosophila CLASP is required for the incorporation of microtubule subunits into fluxing kinetochore fibres.

Authors:  Helder Maiato; Alexey Khodjakov; Conly L Rieder
Journal:  Nat Cell Biol       Date:  2004-12-12       Impact factor: 28.824

6.  Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis.

Authors:  Helder Maiato; Conly L Rieder; Alexey Khodjakov
Journal:  J Cell Biol       Date:  2004-11-29       Impact factor: 10.539

7.  Chromosome motion and the spindle matrix.

Authors:  J Pickett-Heaps; T Spurck; D Tippit
Journal:  J Cell Biol       Date:  1984-07       Impact factor: 10.539

Review 8.  Mitosis, microtubules, and the matrix.

Authors:  J M Scholey; G C Rogers; D J Sharp
Journal:  J Cell Biol       Date:  2001-07-23       Impact factor: 10.539

9.  Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends.

Authors:  G J Gorbsky; P J Sammak; G G Borisy
Journal:  J Cell Biol       Date:  1987-01       Impact factor: 10.539

10.  The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles.

Authors:  David T Miyamoto; Zachary E Perlman; Kendra S Burbank; Aaron C Groen; Timothy J Mitchison
Journal:  J Cell Biol       Date:  2004-12-06       Impact factor: 10.539

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  5 in total

1.  Mitosis: spindle evolution and the matrix model.

Authors:  Jeremy Pickett-Heaps; Art Forer
Journal:  Protoplasma       Date:  2009-03-03       Impact factor: 3.356

2.  Both actin and myosin inhibitors affect spindle architecture in PtK1 cells: does an actomyosin system contribute to mitotic spindle forces by regulating attachment and movements of chromosomes in mammalian cells?

Authors:  Judith A Snyder; Yen Ha; Claire Olsofka; Reema Wahdan
Journal:  Protoplasma       Date:  2009-11-29       Impact factor: 3.356

3.  Meiosis-I in Mesostoma ehrenbergii spermatocytes includes distance segregation and inter-polar movements of univalents, and vigorous oscillations of bivalents.

Authors:  Jessica Ferraro-Gideon; Carina Hoang; Arthur Forer
Journal:  Protoplasma       Date:  2013-08-07       Impact factor: 3.356

Review 4.  Nuclear actin: ancient clue to evolution in eukaryotes?

Authors:  Csaba Bajusz; Péter Borkúti; Ildikó Kristó; Zoltán Kovács; Csilla Abonyi; Péter Vilmos
Journal:  Histochem Cell Biol       Date:  2018-07-17       Impact factor: 4.304

5.  Synchronizing chromosome segregation by flux-dependent force equalization at kinetochores.

Authors:  Irina Matos; António J Pereira; Mariana Lince-Faria; Lisa A Cameron; Edward D Salmon; Helder Maiato
Journal:  J Cell Biol       Date:  2009-07-06       Impact factor: 10.539

  5 in total

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