Literature DB >> 18420457

Molecular tools for the rapid detection of drug resistance in animal trypanosomes.

Vincent Delespaux1, Dirk Geysen, Peter Van den Bossche, Stanny Geerts.   

Abstract

There are currently 17 African countries in which animal trypanocidal drug resistance has been reported. Large-scale surveys were carried out in only ten of them. The lack of baseline information is mainly due to the fact that the methods currently available for the detection of drug resistance are laborious, expensive and time consuming. In this review the mechanisms involved in resistance to isometamidium and diminazene will be discussed, together with some new molecular detection tools that have been developed recently enabling faster diagnosis of drug resistance than conventional laboratory or field tests.

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Year:  2008        PMID： 18420457     DOI： 10.1016/j.pt.2008.02.006

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  38 in total

1.  Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes.

Authors:  Nicola Baker; Graham Hamilton; Jonathan M Wilkes; Sebastian Hutchinson; Michael P Barrett; David Horn
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-06       Impact factor: 11.205

2.  Drug-resistant trypanosome isolates populations in dogs in Enugu North Senatorial Zone, Southeastern Nigeria.

Authors:  Chukwunonso Francis Obi; Michael Ikenna Okpala; Ikenna Onyema Ezeh; Amaechi Onyeabor; Romanus Chukwuduruo Ezeokonkwo
Journal:  Parasitol Res       Date:  2021-11-08       Impact factor: 2.289

3.  Evaluation of In Vitro Activity of Essential Oils against Trypanosoma brucei brucei and Trypanosoma evansi.

Authors:  Nathan Habila; Abel S Agbaji; Zakari Ladan; Isaac A Bello; Emmanuel Haruna; Monday A Dakare; Taofiq O Atolagbe
Journal:  J Parasitol Res       Date:  2010-03-28

4.  Chemosensitization of Trypanosoma congolense strains resistant to isometamidium chloride by tetracyclines and enrofloxacin.

Authors:  Vincent Delespaux; Hervé Sèna Vitouley; Tanguy Marcotty; Niko Speybroeck; Dirk Berkvens; Krisna Roy; Stanny Geerts; Peter Van den Bossche
Journal:  PLoS Negl Trop Dis       Date:  2010-09-28

5.  Mycophenolic Acid and Its Derivatives as Potential Chemotherapeutic Agents Targeting Inosine Monophosphate Dehydrogenase in Trypanosoma congolense.

Authors:  Keisuke Suganuma; Albertus Eka Yudistira Sarwono; Shinya Mitsuhashi; Marcin Jąkalski; Tadashi Okada; Molefe Nthatisi; Junya Yamagishi; Makoto Ubukata; Noboru Inoue
Journal:  Antimicrob Agents Chemother       Date:  2016-06-20       Impact factor: 5.191

6.  Efficacy of diminazene diaceturate and isometamidium chloride hydrochloride for the treatment of Trypanosoma evansi in mice model.

Authors:  Weldegebrial G Aregawi; Fikadu Gutema; Juhar Tesfaye; Abel Sorsa; Brehanu Megersa; Philimon Teshome; Getahun E Agga; Hagos Ashenafi
Journal:  J Parasit Dis       Date:  2020-10-12

7.  Improved PCR-RFLP for the detection of diminazene resistance in Trypanosoma congolense under field conditions using filter papers for sample storage.

Authors:  Hervé Sèna Vitouley; Erick Ouma Mungube; Emmanuel Allegye-Cudjoe; Oumar Diall; Zakaria Bocoum; Boucader Diarra; Thomas F Randolph; Burkhard Bauer; Peter-Henning Clausen; Dirk Geysen; Issa Sidibe; Zakaria Bengaly; Peter Van den Bossche; Vincent Delespaux
Journal:  PLoS Negl Trop Dis       Date:  2011-07-26

8.  High prevalence of drug resistance in animal trypanosomes without a history of drug exposure.

Authors:  Simbarashe Chitanga; Tanguy Marcotty; Boniface Namangala; Peter Van den Bossche; Jan Van Den Abbeele; Vincent Delespaux
Journal:  PLoS Negl Trop Dis       Date:  2011-12-20

9.  A major genetic locus in Trypanosoma brucei is a determinant of host pathology.

Authors:  Liam J Morrison; Andy Tait; Sarah McLellan; Lindsay Sweeney; C Michael R Turner; Annette MacLeod
Journal:  PLoS Negl Trop Dis       Date:  2009-12-01

10.  Detection of multiple drug-resistant Trypanosoma congolense populations in village cattle of south-east Mali.

Authors:  Erick O Mungube; Hervé S Vitouley; Emmanuel Allegye-Cudjoe; Oumar Diall; Zakaria Boucoum; Boucader Diarra; Yousouf Sanogo; Thomas Randolph; Burkhard Bauer; Karl-Hans Zessin; Peter-Henning Clausen
Journal:  Parasit Vectors       Date:  2012-08-01       Impact factor: 3.876
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