| Literature DB >> 18419162 |
Zhaoguang Li1, He Huang, Hongbin Sun, Hualiang Jiang, Hong Liu.
Abstract
An efficient and convenient method was developed for the preparation of 2,4(1H,3H)-quinazolinediones and 2-thioxoquinazolinones. Substituted methyl anthranilate reacted with various iso(thio)cyanates in DMSO/H2O without any catalyst or base by using microwave irradiation to generate diversity on the 2,4(1H,3H)-quinazolinediones or 2-thioxoquinazolinones. A variety of substrates can participate in the process with good yields and high purities, making this methodology suitable for library synthesis in drug discovery efforts.Entities:
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Year: 2008 PMID： 18419162 DOI： 10.1021/cc800040z
Source DB: PubMed Journal: J Comb Chem ISSN： 1520-4766