BACKGROUND: Patients with cognitive impairment no dementia (CIND) are at an increased risk of progression to Alzheimer's disease (AD). Whether subtle impairments in functional or social abilities at the CIND stage can predict progression to AD is not yet fully determined. We evaluated whether impairments on the Disability Assessment for Dementia (DAD) and Functional Rating Scale (FRS) can predict progression to AD. METHODS: We examined 70 patients with CIND from the ACCORD cohort having complete DAD and FRS baseline and 2-year follow-up data. MANCOVA adjusted for age, sex, education and baseline MMSE score compared the baseline and 2-year change in DAD and FRS scores in CIND patients who progressed to AD versus non-progressors. RESULTS: There were no significant differences between CIND progressors and non-progressors in baseline total DAD or FRS scores. FRS domain analysis revealed that greater impairment in social/occupational functioning significantly predicted progression, while there were no predictive DAD domains. In progressors, both DAD and FRS scores significantly declined over time with the largest changes in instrumental activities of daily living (IADL). CONCLUSION: While changes in IADL characterize the progression from CIND to AD, impairment in complex social-cognitive competency significantly predicts risk of progression and may mark early AD. (c) 2008 S. Karger AG, Basel.
BACKGROUND:Patients with cognitive impairment no dementia (CIND) are at an increased risk of progression to Alzheimer's disease (AD). Whether subtle impairments in functional or social abilities at the CIND stage can predict progression to AD is not yet fully determined. We evaluated whether impairments on the Disability Assessment for Dementia (DAD) and Functional Rating Scale (FRS) can predict progression to AD. METHODS: We examined 70 patients with CIND from the ACCORD cohort having complete DAD and FRS baseline and 2-year follow-up data. MANCOVA adjusted for age, sex, education and baseline MMSE score compared the baseline and 2-year change in DAD and FRS scores in CIND patients who progressed to AD versus non-progressors. RESULTS: There were no significant differences between CIND progressors and non-progressors in baseline total DAD or FRS scores. FRS domain analysis revealed that greater impairment in social/occupational functioning significantly predicted progression, while there were no predictive DAD domains. In progressors, both DAD and FRS scores significantly declined over time with the largest changes in instrumental activities of daily living (IADL). CONCLUSION: While changes in IADL characterize the progression from CIND to AD, impairment in complex social-cognitive competency significantly predicts risk of progression and may mark early AD. (c) 2008 S. Karger AG, Basel.
Authors: Melissa L O'Connor; Jerri D Edwards; Virginia G Wadley; Michael Crowe Journal: J Gerontol B Psychol Sci Soc Sci Date: 2010-02-10 Impact factor: 4.077
Authors: Adam Gerstenecker; Kristen L Triebel; Roy Martin; Scott Snyder; Daniel C Marson Journal: Alzheimer Dis Assoc Disord Date: 2016 Jan-Mar Impact factor: 2.703
Authors: Genevera I Allen; Nicola Amoroso; Catalina Anghel; Venkat Balagurusamy; Christopher J Bare; Derek Beaton; Roberto Bellotti; David A Bennett; Kevin L Boehme; Paul C Boutros; Laura Caberlotto; Cristian Caloian; Frederick Campbell; Elias Chaibub Neto; Yu-Chuan Chang; Beibei Chen; Chien-Yu Chen; Ting-Ying Chien; Tim Clark; Sudeshna Das; Christos Davatzikos; Jieyao Deng; Donna Dillenberger; Richard J B Dobson; Qilin Dong; Jimit Doshi; Denise Duma; Rosangela Errico; Guray Erus; Evan Everett; David W Fardo; Stephen H Friend; Holger Fröhlich; Jessica Gan; Peter St George-Hyslop; Satrajit S Ghosh; Enrico Glaab; Robert C Green; Yuanfang Guan; Ming-Yi Hong; Chao Huang; Jinseub Hwang; Joseph Ibrahim; Paolo Inglese; Anandhi Iyappan; Qijia Jiang; Yuriko Katsumata; John S K Kauwe; Arno Klein; Dehan Kong; Roland Krause; Emilie Lalonde; Mario Lauria; Eunjee Lee; Xihui Lin; Zhandong Liu; Julie Livingstone; Benjamin A Logsdon; Simon Lovestone; Tsung-Wei Ma; Ashutosh Malhotra; Lara M Mangravite; Taylor J Maxwell; Emily Merrill; John Nagorski; Aishwarya Namasivayam; Manjari Narayan; Mufassra Naz; Stephen J Newhouse; Thea C Norman; Ramil N Nurtdinov; Yen-Jen Oyang; Yudi Pawitan; Shengwen Peng; Mette A Peters; Stephen R Piccolo; Paurush Praveen; Corrado Priami; Veronica Y Sabelnykova; Philipp Senger; Xia Shen; Andrew Simmons; Aristeidis Sotiras; Gustavo Stolovitzky; Sabina Tangaro; Andrea Tateo; Yi-An Tung; Nicholas J Tustison; Erdem Varol; George Vradenburg; Michael W Weiner; Guanghua Xiao; Lei Xie; Yang Xie; Jia Xu; Hojin Yang; Xiaowei Zhan; Yunyun Zhou; Fan Zhu; Hongtu Zhu; Shanfeng Zhu Journal: Alzheimers Dement Date: 2016-04-11 Impact factor: 21.566