BACKGROUND: Cytokines play an important role in skin inflammation. OBJECTIVES: We determined whether polymorphisms in cytokine genes contribute to the occurrence of occupational chronic irritant contact dermatitis (CICD). METHODS: In a case-control study, 9 polymorphisms in the genes coding for interleukin (IL)-1 alpha, IL-1 beta, IL-8, IL-10, and tumour necrosis factor (TNF)-alpha were determined in 197 patients with CICD. 217 apprentices in vocational training for high-risk occupations for CICD served as controls. RESULTS: For all polymorphisms, no differences in genotype distributions were found between patients and controls. However, in patients with self-reported low levels of wet work and irritant exposure, more TNFA -308 variant genotypes (G/A and A/A) were present compared with those exposed to higher levels or controls, which indicates a TNFA-induced increase of susceptibility. In patients with TNFA -308 variant genotypes, the prevalence of flexural eczema was higher (48% and 57%) compared with that in patients presented with wild-type genotype (30%). Regarding IL1A -889, prevalence of symptoms of dermatitis was lower in apprentices with T/T or C/T genotype (32% and 36%) compared with wild-type genotype (54%, C/C). This indicates a protective effect of these variant alleles in acquiring hand dermatitis. CONCLUSIONS: This study provides evidence that some genetic variations alter susceptibility to (chronic) dermatitis. Knowledge of the impact of genetic differences on the risk of CICD is essential in predictive testing of individuals at risk.
BACKGROUND: Cytokines play an important role in skin inflammation. OBJECTIVES: We determined whether polymorphisms in cytokine genes contribute to the occurrence of occupational chronic irritant contact dermatitis (CICD). METHODS: In a case-control study, 9 polymorphisms in the genes coding for interleukin (IL)-1 alpha, IL-1 beta, IL-8, IL-10, and tumour necrosis factor (TNF)-alpha were determined in 197 patients with CICD. 217 apprentices in vocational training for high-risk occupations for CICD served as controls. RESULTS: For all polymorphisms, no differences in genotype distributions were found between patients and controls. However, in patients with self-reported low levels of wet work and irritant exposure, more TNFA -308 variant genotypes (G/A and A/A) were present compared with those exposed to higher levels or controls, which indicates a TNFA-induced increase of susceptibility. In patients with TNFA -308 variant genotypes, the prevalence of flexural eczema was higher (48% and 57%) compared with that in patients presented with wild-type genotype (30%). Regarding IL1A -889, prevalence of symptoms of dermatitis was lower in apprentices with T/T or C/T genotype (32% and 36%) compared with wild-type genotype (54%, C/C). This indicates a protective effect of these variant alleles in acquiring hand dermatitis. CONCLUSIONS: This study provides evidence that some genetic variations alter susceptibility to (chronic) dermatitis. Knowledge of the impact of genetic differences on the risk of CICD is essential in predictive testing of individuals at risk.
Authors: James J Lee; Cheryl A Protheroe; Huijun Luo; Sergei I Ochkur; Gregory D Scott; Katie R Zellner; Randall J Raish; Mark V Dahl; Miriam L Vega; Olivia Conley; Rachel M Condjella; Jake A Kloeber; Joseph L Neely; Yash S Patel; Patty Maizer; Andrew Mazzolini; Allison D Fryer; Noah W Jacoby; David B Jacoby; Nancy A Lee Journal: J Allergy Clin Immunol Date: 2014-08-13 Impact factor: 10.793
Authors: Berran Yucesoy; Yerkebulan Talzhanov; M Michael Barmada; Victor J Johnson; Michael L Kashon; Elma Baron; Nevin W Wilson; Bonnie Frye; Wei Wang; Kara Fluharty; Rola Gharib; Jean Meade; Dori Germolec; Michael I Luster; Susan Nedorost Journal: J Occup Environ Med Date: 2016-08 Impact factor: 2.162
Authors: Berran Yucesoy; Yerkebulan Talzhanov; M Michael Barmada; Victor J Johnson; Michael L Kashon; Elma Baron; Nevin W Wilson; Bonnie Frye; Wei Wang; Kara Fluharty; Rola Gharib; Jean Meade; Dori Germolec; Michael I Luster; Susan Nedorost Journal: J Immunotoxicol Date: 2016-06-03 Impact factor: 3.000
Authors: Martijn D F Rhebergen; Maaike J Visser; Maarten M Verberk; Annet F Lenderink; Frank J H van Dijk; Sanja Kezic; Carel T J Hulshof Journal: J Community Genet Date: 2012-02-09
Authors: Marcela Caleffi da Costa Lima Caniatti; Ariella Andrade Marchioro; Ana Lúcia Falavigna Guilherme; Luiza Tamie Tsuneto Journal: PLoS One Date: 2014-09-19 Impact factor: 3.240
Authors: M J Visser; L Landeck; L E Campbell; W H I McLean; S Weidinger; F Calkoen; S M John; S Kezic Journal: Br J Dermatol Date: 2013-02 Impact factor: 9.302