Literature DB >> 18413709

Fine-tuning of hematopoietic stem cell homeostasis: novel role for ubiquitin ligase.

Tomomasa Yokomizo1, Elaine Dzierzak.   

Abstract

Homeostasis of hematopoietic stem cells (HSCs) is a tightly regulated process, controlled by intrinsic and extrinsic signals. Although a variety of molecules involved in HSC maintenance and self-renewal are known, it remains unclear how robust HSC homeostasis is achieved. In this issue of Genes & Development, Rathinam and colleagues (992-997) report a new player in HSC homeostasis, c-Cbl ubiquitin ligase. They show that this E3 ubiquitin ligase acts as a negative regulator of cytokine signaling.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18413709      PMCID： PMC2732392          DOI： 10.1101/gad.1669908

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  46 in total

Review 1.  The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling.

Authors:  Lei Duan; Alagarsamy Lakku Reddi; Amiya Ghosh; Manjari Dimri; Hamid Band
Journal:  Immunity       Date:  2004-07       Impact factor: 31.745

2.  Phosphatidylinositol 3-kinase is necessary but not sufficient for thrombopoietin-induced proliferation in engineered Mpl-bearing cell lines as well as in primary megakaryocytic progenitors.

Authors:  A E Geddis; N E Fox; K Kaushansky
Journal:  J Biol Chem       Date:  2001-06-20       Impact factor: 5.157

3.  Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis.

Authors:  P Rojnuckarin; J G Drachman; K Kaushansky
Journal:  Blood       Date:  1999-08-15       Impact factor: 22.113

4.  Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity.

Authors:  J Adolfsson; O J Borge; D Bryder; K Theilgaard-Mönch; I Astrand-Grundström; E Sitnicka; Y Sasaki; S E Jacobsen
Journal:  Immunity       Date:  2001-10       Impact factor: 31.745

5.  RTCGD: retroviral tagged cancer gene database.

Authors:  Keiko Akagi; Takeshi Suzuki; Robert M Stephens; Nancy A Jenkins; Neal G Copeland
Journal:  Nucleic Acids Res       Date:  2004-01-01       Impact factor: 16.971

6.  Identification of the haematopoietic stem cell niche and control of the niche size.

Authors:  Jiwang Zhang; Chao Niu; Ling Ye; Haiyang Huang; Xi He; Wei-Gang Tong; Jason Ross; Jeff Haug; Teri Johnson; Jian Q Feng; Stephen Harris; Leanne M Wiedemann; Yuji Mishina; Linheng Li
Journal:  Nature       Date:  2003-10-23       Impact factor: 49.962

7.  Osteoblastic cells regulate the haematopoietic stem cell niche.

Authors:  L M Calvi; G B Adams; K W Weibrecht; J M Weber; D P Olson; M C Knight; R P Martin; E Schipani; P Divieti; F R Bringhurst; L A Milner; H M Kronenberg; D T Scadden
Journal:  Nature       Date:  2003-10-23       Impact factor: 49.962

8.  Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.

Authors:  Fumio Arai; Atsushi Hirao; Masako Ohmura; Hidetaka Sato; Sahoko Matsuoka; Keiyo Takubo; Keisuke Ito; Gou Young Koh; Toshio Suda
Journal:  Cell       Date:  2004-07-23       Impact factor: 41.582

9.  Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival.

Authors:  Hanno Hock; Eliza Meade; Sarah Medeiros; Jeffrey W Schindler; Peter J M Valk; Yuko Fujiwara; Stuart H Orkin
Journal:  Genes Dev       Date:  2004-09-15       Impact factor: 11.361

10.  Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis.

Authors:  Mira C Puri; Alan Bernstein
Journal:  Proc Natl Acad Sci U S A       Date:  2003-10-06       Impact factor: 11.205
View more
  7 in total

1.  c-Cbl deficiency leads to diminished lymphocyte development and functions in an age-dependent manner.

Authors:  Chozhavendan Rathinam; Richard A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-19       Impact factor: 11.205

2.  Foe turned friend: multiple functional roles attributable to hyper-activating stem cell factor receptor mutant in regeneration of the haematopoietic cell compartment.

Authors:  S Pati; O P Kalra; A Mukhopadhyay
Journal:  Cell Prolif       Date:  2011-02       Impact factor: 6.831

3.  The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells.

Authors:  Chozhavendan Rathinam; Lydia E Matesic; Richard A Flavell
Journal:  Nat Immunol       Date:  2011-04-10       Impact factor: 25.606

4.  Differential modulation of TCF/LEF-1 activity by the soluble LRP6-ICD.

Authors:  Brandon Beagle; Gail V W Johnson
Journal:  PLoS One       Date:  2010-07-28       Impact factor: 3.240

5.  Cumulative PM(2.5) exposure and telomere length in workers exposed to welding fumes.

Authors:  Jason Y Y Wong; Immaculata De Vivo; Xihong Lin; David C Christiani
Journal:  J Toxicol Environ Health A       Date:  2014

6.  The 'inflammatory' control of hematopoietic stem cells.

Authors:  Chozha Rathinam
Journal:  Oncotarget       Date:  2015-08-21

Review 7.  E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration.

Authors:  Arun Upadhyay; Vibhuti Joshi; Ayeman Amanullah; Ribhav Mishra; Naina Arora; Amit Prasad; Amit Mishra
Journal:  Front Mol Neurosci       Date:  2017-05-19       Impact factor: 5.639
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.