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Literature DB >> 15371326

Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival.

Hanno Hock¹, Eliza Meade, Sarah Medeiros, Jeffrey W Schindler, Peter J M Valk, Yuko Fujiwara, Stuart H Orkin.

Abstract

Hematopoietic stem cells (HSCs) sustain blood formation throughout life. Pathways regulating maintenance of adult HSCs are largely unknown. Here we report that the Ets-related transcription factor Tel/Etv6, the product of a locus frequently involved in translocations in leukemia, is a selective regulator of HSC survival. Following inactivation of Tel/Etv6, HSCs are lost in the adult bone marrow but their progeny are unaffected and transiently sustain blood formation. Accordingly, absence of Tel/Etv6 after lineage commitment is ostensibly without consequence except for unexpected impairment of maturation of megakaryocytes. Thus, we establish Tel/Etv6 as a selective and essential regulator of postembryonic HSCs. Copyright 2004 Cold Spring Harbor Laboratory Press

Entities: Disease Gene

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Year: 2004 PMID： 15371326 PMCID： PMC522982 DOI： 10.1101/gad.1239604

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

31 in total

Review 1. Diversification of haematopoietic stem cells to specific lineages.

Authors: S H Orkin
Journal: Nat Rev Genet Date: 2000-10 Impact factor: 53.242

2. Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells.

Authors: Keiki Kumano; Shigeru Chiba; Atsushi Kunisato; Masataka Sata; Toshiki Saito; Etsuko Nakagami-Yamaguchi; Tomoyuki Yamaguchi; Shigeo Masuda; Kiyoshi Shimizu; Tokiharu Takahashi; Seishi Ogawa; Yoshio Hamada; Hisamaru Hirai
Journal: Immunity Date: 2003-05 Impact factor: 31.745

3. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene.

Authors: Hanna K A Mikkola; Jenny Klintman; Haidi Yang; Hanno Hock; Thorsten M Schlaeger; Yuko Fujiwara; Stuart H Orkin
Journal: Nature Date: 2003-01-19 Impact factor: 49.962

4. Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors.

Authors: Xun Wang; John D Crispino; Danielle L Letting; Minako Nakazawa; Mortimer Poncz; Gerd A Blobel
Journal: EMBO J Date: 2002-10-01 Impact factor: 11.598

Review 5. Megakaryocytes and beyond: the birth of platelets.

Authors: J E Italiano; R A Shivdasani
Journal: J Thromb Haemost Date: 2003-06 Impact factor: 5.824

6. Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.

Authors: Cord Brakebusch; Simon Fillatreau; Alexandre J Potocnik; Gerd Bungartz; Patricia Wilhelm; Marcus Svensson; Phil Kearney; Heinrich Körner; David Gray; Reinhard Fässler
Journal: Immunity Date: 2002-03 Impact factor: 31.745

7. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision.

Authors: Hua Han; Kenji Tanigaki; Norio Yamamoto; Kazuki Kuroda; Momoko Yoshimoto; Tatsutoshi Nakahata; Koichi Ikuta; Tasuku Honjo
Journal: Int Immunol Date: 2002-06 Impact factor: 4.823

8. Deficient T cell fate specification in mice with an induced inactivation of Notch1.

Authors: F Radtke; A Wilson; G Stark; M Bauer; J van Meerwijk; H R MacDonald; M Aguet
Journal: Immunity Date: 1999-05 Impact factor: 31.745

9. Hematopoietic stem cell quiescence maintained by p21cip1/waf1.

Authors: T Cheng; N Rodrigues; H Shen; Y Yang; D Dombkowski; M Sykes; D T Scadden
Journal: Science Date: 2000-03-10 Impact factor: 47.728

10. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism.

Authors: Hans-Peter Gerber; Ajay K Malik; Gregg P Solar; Daniel Sherman; Xiao Huan Liang; Gloria Meng; Kyu Hong; James C Marsters; Napoleone Ferrara
Journal: Nature Date: 2002-06-27 Impact factor: 49.962

110 in total

Review 1. Plasticity and maintenance of hematopoietic stem cells during development.

Authors: Suman Kanji; Vincent J Pompili; Hiranmoy Das
Journal: Recent Pat Biotechnol Date: 2011-04

2. GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells.

Authors: Shuyang Yu; Kairong Cui; Raja Jothi; Dong-Mei Zhao; Xuefang Jing; Keji Zhao; Hai-Hui Xue
Journal: Blood Date: 2010-12-07 Impact factor: 22.113

Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival.

Review 1. Diversification of haematopoietic stem cells to specific lineages.

2. Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells.

3. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene.

4. Control of megakaryocyte-specific gene expression by GATA-1 and FOG-1: role of Ets transcription factors.

Review 5. Megakaryocytes and beyond: the birth of platelets.

6. Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.

7. Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision.

8. Deficient T cell fate specification in mice with an induced inactivation of Notch1.

9. Hematopoietic stem cell quiescence maintained by p21cip1/waf1.

10. VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism.

Review 1. Plasticity and maintenance of hematopoietic stem cells during development.

2. GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells.

3. Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity.

Review 4. ETV6 in hematopoiesis and leukemia predisposition.

5. TEL/ETV6 binds to corepressor KAP1 via the HLH domain.

6. Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells.

7. Luteinizing hormone signaling restricts hematopoietic stem cell expansion during puberty.

8. Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages.

9. Conditional MN1-TEL knock-in mice develop acute myeloid leukemia in conjunction with overexpression of HOXA9.

10. MLL5 contributes to hematopoietic stem cell fitness and homeostasis.