BACKGROUND: Translation initiation is a basic and universal biological process that employs significantly different components and displays substantially different mechanisms in bacterial, archaeal and eukaryotic cells. A large amount of detailed mechanistic and structural information on the bacterial translation initiation apparatus has been uncovered in recent years. OBJECTIVE: to understand which translation initiation steps could represent a novel or underexploited target for the discovery of new and specific antibacterial drugs. METHODS: Brief descriptions of the properties and mechanism of action of the major antibiotics that have a documented direct inhibitory effect on bacterial translation initiation are presented. RESULTS/ CONCLUSIONS: Considerations and predictions concerning a future scenario for research and identification of bacterial translation initiation inhibitors are presented.
BACKGROUND: Translation initiation is a basic and universal biological process that employs significantly different components and displays substantially different mechanisms in bacterial, archaeal and eukaryotic cells. A large amount of detailed mechanistic and structural information on the bacterial translation initiation apparatus has been uncovered in recent years. OBJECTIVE: to understand which translation initiation steps could represent a novel or underexploited target for the discovery of new and specific antibacterial drugs. METHODS: Brief descriptions of the properties and mechanism of action of the major antibiotics that have a documented direct inhibitory effect on bacterial translation initiation are presented. RESULTS/ CONCLUSIONS: Considerations and predictions concerning a future scenario for research and identification of bacterial translation initiation inhibitors are presented.
Authors: Beatriz Llano-Sotelo; Robyn P Hickerson; Laura Lancaster; Harry F Noller; Alexander S Mankin Journal: RNA Date: 2009-06-24 Impact factor: 4.942
Authors: Attilio Fabbretti; Andreas Schedlbauer; Letizia Brandi; Tatsuya Kaminishi; Anna Maria Giuliodori; Raffaella Garofalo; Borja Ochoa-Lizarralde; Chie Takemoto; Shigeyuki Yokoyama; Sean R Connell; Claudio O Gualerzi; Paola Fucini Journal: Proc Natl Acad Sci U S A Date: 2016-04-06 Impact factor: 11.205
Authors: Fabio Di Pietro; Anna Brandi; Nadire Dzeladini; Attilio Fabbretti; Thomas Carzaniga; Lolita Piersimoni; Cynthia L Pon; Anna Maria Giuliodori Journal: Microbiologyopen Date: 2013-02-19 Impact factor: 3.139