| Literature DB >> 18407213 |
Abstract
COUP-TFs are orphan members of the steroid/thyroid hormone receptor superfamily. They are transcription factors that are highly conserved across species and have a wide spectrum of binding specificity. In tissue cultures, COUP-TFs repress the transactivation function of several other members of the steroid/thyroid hormone receptor superfamily, and they also negatively regulate the transcription from promoters of many other genes. The expression profile of COUP-TFs in several species suggests that they play an important role in development and differentiation.Entities:
Year: 1994 PMID: 18407213 DOI: 10.1016/1043-2760(94)p3081-h
Source DB: PubMed Journal: Trends Endocrinol Metab ISSN: 1043-2760 Impact factor: 12.015