Literature DB >> 24878540

COUP-TFs and eye development.

Ke Tang1, Sophia Y Tsai2, Ming-Jer Tsai3.   

Abstract

Recent studies reveal that COUP-TF genes are essential for neural development, cardiovascular development, energy metabolism and adipogenesis, as well as for organogenesis of multiple systems. In this review, we mainly describe the COUP-TF genes, molecular mechanisms of COUP-TF action, and their crucial functions in the morphogenesis of the murine eye. Mutations of COUP-TF genes lead to the congenital coloboma and/or optic atrophy in both mouse and human, indicating that the study on COUP-TFs and the eye will benefit our understanding of the etiology of human ocular diseases. This article is part of a Special Issue entitled: Nuclear receptors in animal development.
Copyright © 2014 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  COUP-TFI; COUP-TFII; Development; Eye

Mesh:

Substances:

Year:  2014        PMID: 24878540      PMCID: PMC4246046          DOI: 10.1016/j.bbagrm.2014.05.022

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  139 in total

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Authors:  P Tran; X K Zhang; G Salbert; T Hermann; J M Lehmann; M Pfahl
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