Literature DB >> 11094155

Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3).

A Kaptein1, M Jansen, G Dilaver, J Kitson, L Dash, E Wang, M J Owen, J L Bodmer, J Tschopp, S N Farrow.   

Abstract

WSL-1/TRAMP (DR3) is a member of the tumour necrosis factor (TNF) receptor superfamily which exhibits effects on NF-kappaB activation and apoptosis. TWEAK, a novel TNF-related molecule, has been proposed as the ligand for this receptor. Utilising both human and murine TWEAK ligand, it is shown that TWEAK and WSL-1/TRAMP do not interact in an in vitro binding assay and that TWEAK binds strongly to cells that do not express WSL-1/TRAMP on the cell surface. Biological activity of TWEAK is also observed in these cells. Finally, cells isolated from WSL-1/TRAMP knockout mice are shown to retain their ability to interact with TWEAK. These results suggest that WSL-1/TRAMP is not the major receptor for TWEAK

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 11094155     DOI： 10.1016/s0014-5793(00)02219-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  15 in total

1.  On death receptor 3 and its ligands….

Authors:  Eddie C Y Wang
Journal:  Immunology       Date:  2012-09       Impact factor: 7.397

Review 2.  The TWEAK-Fn14 system as a potential drug target.

Authors:  Harald Wajant
Journal:  Br J Pharmacol       Date:  2013-10       Impact factor: 8.739

3.  Aberrant expression and function of death receptor-3 and death decoy receptor-3 in human cancer.

Authors:  Zhicheng Ge; Andrew J Sanders; Lin Ye; Wen G Jiang
Journal:  Exp Ther Med       Date:  2011-01-20       Impact factor: 2.447

Review 4.  Tumor necrosis factor-like weak inducer of apoptosis and its potential roles in lupus nephritis.

Authors:  Zhi-Chun Liu; Qiao-Ling Zhou
Journal:  Inflamm Res       Date:  2012-04       Impact factor: 4.575

5.  Proinflammatory effects of tumour necrosis factor-like weak inducer of apoptosis (TWEAK) on human gingival fibroblasts.

Authors:  Y Hosokawa; I Hosokawa; K Ozaki; H Nakae; T Matsuo
Journal:  Clin Exp Immunol       Date:  2006-12       Impact factor: 4.330

Review 6.  TNF superfamily: a growing saga of kidney injury modulators.

Authors:  Maria D Sanchez-Niño; Alberto Benito-Martin; Sara Gonçalves; Ana B Sanz; Alvaro C Ucero; Maria C Izquierdo; Adrian M Ramos; Sergio Berzal; Rafael Selgas; Marta Ruiz-Ortega; Jesus Egido; Alberto Ortiz
Journal:  Mediators Inflamm       Date:  2010-10-04       Impact factor: 4.711

7.  Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants.

Authors:  Rafia S Al-Lamki; Jun Wang; Sathia Thiru; Nicholas R Pritchard; J Andrew Bradley; Jordan S Pober; John R Bradley
Journal:  Am J Pathol       Date:  2003-08       Impact factor: 4.307

Review 8.  The TWEAK-Fn14 cytokine-receptor axis: discovery, biology and therapeutic targeting.

Authors:  Jeffrey A Winkles
Journal:  Nat Rev Drug Discov       Date:  2008-05       Impact factor: 84.694

9.  The Fn14 cytoplasmic tail binds tumour-necrosis-factor-receptor-associated factors 1, 2, 3 and 5 and mediates nuclear factor-kappaB activation.

Authors:  Sharron A N Brown; Christine M Richards; Heather N Hanscom; Sheau-Line Y Feng; Jeffrey A Winkles
Journal:  Biochem J       Date:  2003-04-15       Impact factor: 3.857

10.  Age-dependent maintenance of motor control and corticostriatal innervation by death receptor 3.

Authors:  Jason Peter Twohig; Malcolm I Roberts; Nuria Gavalda; Emma L Rees-Taylor; Albert Giralt; Debbie Adams; Simon P Brooks; Melanie J Bull; Claudia J Calder; Simone Cuff; Audrey A Yong; Jordi Alberch; Alun Davies; Stephen B Dunnett; Aviva M Tolkovsky; Eddie C Y Wang
Journal:  J Neurosci       Date:  2010-03-10       Impact factor: 6.167
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.