OBJECTIVE: To identify an optimal cut-point score on the Mini-Asthma Quality of Life Questionnaire (mini-AQLQ) to predict subsequent asthma exacerbations, and to determine the additional risk conferred by a prior history of acute episodes. STUDY DESIGN: Cross-sectional survey linked to administrative records. METHODS: A total of 1006 HMO patients with active asthma completed surveys that included the mini-AQLQ and prior-year history of acute episodes. Surveys were linked to administrative data that captured asthma emergency department and hospital care (emergency hospital care) for the year after the survey. Optimal mini-AQLQ cut-point scores were determined by stepwise logistic regression analyses using subsequentyear asthma emergency hospital care as the outcome and various mini-AQLQ cut-points as the predictors. Predictive properties of the 2 risk factors (mini-AQLQ cut-points and prior acute episodes) were determined. RESULTS: A mini-AQLQ cut-point of 4.7 was most significantly associated with subsequent exacerbations in patients without a history of prior acute episodes. The presence of either a mini-AQLQ score <4.7 or a history of prior acute episodes provided high sensitivity (90.4%) and identified a group nearly 6 times more likely to require emergency hospital care than patients with neither risk factor. The presence of both risk factors provided high specificity (79.2%) and resulted in a risk ratio of 9.5 compared with the absence of both risk factors. CONCLUSION: Asthma-specific quality of life and a history of acute episodes can be used together to identify patients with clinically meaningful higher and lower risks of subsequent acute exacerbations.
OBJECTIVE: To identify an optimal cut-point score on the Mini-Asthma Quality of Life Questionnaire (mini-AQLQ) to predict subsequent asthma exacerbations, and to determine the additional risk conferred by a prior history of acute episodes. STUDY DESIGN: Cross-sectional survey linked to administrative records. METHODS: A total of 1006 HMO patients with active asthma completed surveys that included the mini-AQLQ and prior-year history of acute episodes. Surveys were linked to administrative data that captured asthma emergency department and hospital care (emergency hospital care) for the year after the survey. Optimal mini-AQLQ cut-point scores were determined by stepwise logistic regression analyses using subsequentyear asthma emergency hospital care as the outcome and various mini-AQLQ cut-points as the predictors. Predictive properties of the 2 risk factors (mini-AQLQ cut-points and prior acute episodes) were determined. RESULTS: A mini-AQLQ cut-point of 4.7 was most significantly associated with subsequent exacerbations in patients without a history of prior acute episodes. The presence of either a mini-AQLQ score <4.7 or a history of prior acute episodes provided high sensitivity (90.4%) and identified a group nearly 6 times more likely to require emergency hospital care than patients with neither risk factor. The presence of both risk factors provided high specificity (79.2%) and resulted in a risk ratio of 9.5 compared with the absence of both risk factors. CONCLUSION: Asthma-specific quality of life and a history of acute episodes can be used together to identify patients with clinically meaningful higher and lower risks of subsequent acute exacerbations.
Authors: Michael E Wechsler; Michel Laviolette; Adalberto S Rubin; Jussara Fiterman; Jose R Lapa e Silva; Pallav L Shah; Elie Fiss; Ronald Olivenstein; Neil C Thomson; Robert M Niven; Ian D Pavord; Michael Simoff; Jeff B Hales; Charlene McEvoy; Dirk-Jan Slebos; Mark Holmes; Martin J Phillips; Serpil C Erzurum; Nicola A Hanania; Kaharu Sumino; Monica Kraft; Gerard Cox; Daniel H Sterman; Kyle Hogarth; Joel N Kline; Adel H Mansur; Brian E Louie; William M Leeds; Richard G Barbers; John H M Austin; Narinder S Shargill; John Quiring; Brian Armstrong; Mario Castro Journal: J Allergy Clin Immunol Date: 2013-08-30 Impact factor: 10.793
Authors: Mario Castro; Adalberto S Rubin; Michel Laviolette; Jussara Fiterman; Marina De Andrade Lima; Pallav L Shah; Elie Fiss; Ronald Olivenstein; Neil C Thomson; Robert M Niven; Ian D Pavord; Michael Simoff; David R Duhamel; Charlene McEvoy; Richard Barbers; Nicolaas H T Ten Hacken; Michael E Wechsler; Mark Holmes; Martin J Phillips; Serpil Erzurum; William Lunn; Elliot Israel; Nizar Jarjour; Monica Kraft; Narinder S Shargill; John Quiring; Scott M Berry; Gerard Cox Journal: Am J Respir Crit Care Med Date: 2009-10-08 Impact factor: 21.405
Authors: Neil C Thomson; Adalberto S Rubin; Robert M Niven; Paul A Corris; Hans Christian Siersted; Ronald Olivenstein; Ian D Pavord; David McCormack; Michel Laviolette; Narinder S Shargill; Gerard Cox Journal: BMC Pulm Med Date: 2011-02-11 Impact factor: 3.317
Authors: Jonathan M Feldman; Jacqueline Becker; Arushi Arora; Jesenya DeLeon; Tatiana Torres-Hernandez; Naomi Greenfield; Allyana Wiviott; Sunit Jariwala; Chang Shim; Alex D Federman; Juan P Wisnivesky Journal: Psychosom Med Date: 2021-09-01 Impact factor: 3.864
Authors: Francisco-Javier Gonzalez-Barcala; Ramon de la Fuente-Cid; Mónica Tafalla; Javier Nuevo; Francisco Caamaño-Isorna Journal: Multidiscip Respir Med Date: 2012-10-02