Literature DB >> 18401500

Role and substrate specificity of the Streptomyces coelicolor RedH enzyme in undecylprodiginine biosynthesis.

Stuart W Haynes1, Paulina K Sydor, Anna E Stanley, Lijiang Song, Gregory L Challis.   

Abstract

The function of RedH from Streptomyces coelicolor as an enzyme that catalyses the condensation of 4-methoxy-2,2'-bipyrrole-5-carboxaldehyde (MBC) and 2-undecylpyrrole to form the natural product undecylprodiginine has been experimentally proven, and the substrate specificity of RedH has been probed in vivo by examining its ability to condense chemically-synthesised MBC analogues with 2-undecylpyrrole to afford undecylprodiginine analogues.

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Year:  2008        PMID： 18401500     DOI： 10.1039/b801677a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  14 in total

1.  Enzyme catalysis: C-H activation is a Reiske business.

Authors:  Steven D Bruner
Journal:  Nat Chem       Date:  2011-05       Impact factor: 24.427

Review 2.  Oxidative Cyclization in Natural Product Biosynthesis.

Authors:  Man-Cheng Tang; Yi Zou; Kenji Watanabe; Christopher T Walsh; Yi Tang
Journal:  Chem Rev       Date:  2016-12-12       Impact factor: 60.622

3.  RedH and PigC Catalyze the Biosynthesis of Hybrubins via Phosphorylation of 4'-Methoxy-2,2'-Bipyrrole-5'-Carbaldehyde.

Authors:  Qingshan Long; Daniel E Jeffries; Shuangjun Lin; Xuefei Chen; Weijun He; Yemin Wang; Zixin Deng; Craig W Lindsley; Meifeng Tao
Journal:  Appl Environ Microbiol       Date:  2020-01-07       Impact factor: 4.792

4.  Large-Scale Transposition Mutagenesis of Streptomyces coelicolor Identifies Hundreds of Genes Influencing Antibiotic Biosynthesis.

Authors:  Zhong Xu; Yemin Wang; Keith F Chater; Hong-Yu Ou; H Howard Xu; Zixin Deng; Meifeng Tao
Journal:  Appl Environ Microbiol       Date:  2017-03-02       Impact factor: 4.792

5.  Elimination of butylcycloheptylprodigiosin as a known natural product inspired by an evolutionary hypothesis for cyclic prodigiosin biosynthesis.

Authors:  Brian T Jones; Dennis X Hu; Brett M Savoie; Regan J Thomson
Journal:  J Nat Prod       Date:  2013-09-20       Impact factor: 4.050

6.  Structure and function of the RedJ protein, a thioesterase from the prodiginine biosynthetic pathway in Streptomyces coelicolor.

Authors:  Jonathan R Whicher; Galina Florova; Paulina K Sydor; Renu Singh; Mamoun Alhamadsheh; Gregory L Challis; Kevin A Reynolds; Janet L Smith
Journal:  J Biol Chem       Date:  2011-05-03       Impact factor: 5.157

Review 7.  Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways.

Authors:  Gregory L Challis
Journal:  J Ind Microbiol Biotechnol       Date:  2013-12-10       Impact factor: 3.346

8.  Modular access to complex prodiginines: total synthesis of (+)-roseophilin via its 2-azafulvene prototropisomer.

Authors:  James H Frederich; Patrick G Harran
Journal:  J Am Chem Soc       Date:  2013-03-01       Impact factor: 15.419

Review 9.  Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products.

Authors:  Dennis X Hu; David M Withall; Gregory L Challis; Regan J Thomson
Journal:  Chem Rev       Date:  2016-06-17       Impact factor: 60.622

10.  Mechanism and Catalytic Diversity of Rieske Non-Heme Iron-Dependent Oxygenases.

Authors:  Sarah M Barry; Gregory L Challis
Journal:  ACS Catal       Date:  2013-10-04       Impact factor: 13.084
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