| Literature DB >> 18400395 |
Christine Gerin1, Jean-Rene Teilhac, Kristin Smith, Alain Privat.
Abstract
Literature highlights that serotonergic descending pathways are implicated in somatosensory functions in the spinal cord and that serotonin (5-HT) in the dorsal horn might play a role in motor function through proprioceptive feedback. We hypothesized that 5-HT release in dorsal horn might represent an important factor in the completion of locomotion by facilitation of the spinocerebellar tract and/or by modulation of spinal reflex pathways. The present study demonstrates that during locomotor activity, 5-HT is released in layers II, III, IV, V of Rexed. Microdialysis in combination with HPLC was used to measure concentrations of neurotransmitters in the lumbar dorsal horn before, during, and after a treadmill running exercise. Our results show a significant 41% increase of 5-HT release within the dorsal horn during the exercise. 5-HT release is temporally related to exercise. The present study demonstrates that dorsal horn 5-HT release might modulate locomotion.Entities:
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Year: 2008 PMID： 18400395 PMCID： PMC2699369 DOI： 10.1016/j.neulet.2008.01.081
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046