| Literature DB >> 19774460 |
Arthiese Korb1, Leandro Viçosa Bonetti, Sandro Antunes da Silva, Simone Marcuzzo, Jocemar Ilha, Mariane Bertagnolli, Wania Aparecida Partata, Maria Cristina Faccioni-Heuser.
Abstract
The serotoninergic system modulates nociceptive and locomotor spinal cord circuits. Exercise improves motor function and changes dopaminergic, noradrenergic, and serotonergic central systems. However, the direct relationship between serotonin, peripheral nerve lesion and aerobic treadmill exercise has not been studied. Using immunohistochemistry and optic densitometry, this study showed that the sciatic nerve transection increased the serotoninergic immunoreactivity in neuronal cytoplasm of the magnus raphe nuclei of trained and sedentary rats. In the dorsal raphe nucleus the increase only occurred in sedentary-sham-operated rats. In the spinal cord of trained, transected rats, the ventral horn showed significant changes, while the change in dorsal horn was insignificant. Von Frey's test indicated analgesia in all exercise-trained rats. The sciatic nerve functional index indicated recovery in the trained group. Thus, both the aerobic treadmill exercise training and the nervous lesion appear to contribute to changes in serotonin immunoreactivity.Entities:
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Year: 2009 PMID： 19774460 DOI： 10.1007/s11064-009-0066-x
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996