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Literature DB >> 18397738

mRNA export: RNP remodeling by DEAD-box proteins.

Abstract

The DEAD-box protein Dbp5 was thought to remodel ribonucleoproteins and displace proteins from these complexes in an ATP-dependent fashion to allow for mRNA export from the nucleus. A recent study on Dbp5 shows, however, that its ADP-bound form may also perform an important function in displacing export factors from mRNA.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2008 PMID： 18397738 DOI： 10.1016/j.cub.2008.02.027

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834

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Cited

18 in total

Review 1. Transcription and post-transcriptional regulation of spermatogenesis.

Authors: Anilkumar Bettegowda; Miles F Wilkinson
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2010-05-27 Impact factor: 6.237

Review 2. Roles of DEAD-box proteins in RNA and RNP Folding.

Authors: Cynthia Pan; Rick Russell
Journal: RNA Biol Date: 2010-11-01 Impact factor: 4.652

3. ATP-dependent roles of the DEAD-box protein Mss116p in group II intron splicing in vitro and in vivo.

Authors: Jeffrey P Potratz; Mark Del Campo; Rachel Z Wolf; Alan M Lambowitz; Rick Russell
Journal: J Mol Biol Date: 2011-06-07 Impact factor: 5.469

4. The Dbp5 cycle at the nuclear pore complex during mRNA export I: dbp5 mutants with defects in RNA binding and ATP hydrolysis define key steps for Nup159 and Gle1.

Authors: Christine A Hodge; Elizabeth J Tran; Kristen N Noble; Abel R Alcazar-Roman; Rakefet Ben-Yishay; John J Scarcelli; Andrew W Folkmann; Yaron Shav-Tal; Susan R Wente; Charles N Cole
Journal: Genes Dev Date: 2011-05-15 Impact factor: 11.361

mRNA export: RNP remodeling by DEAD-box proteins.

Review 1. Transcription and post-transcriptional regulation of spermatogenesis.

Review 2. Roles of DEAD-box proteins in RNA and RNP Folding.

3. ATP-dependent roles of the DEAD-box protein Mss116p in group II intron splicing in vitro and in vivo.

4. The Dbp5 cycle at the nuclear pore complex during mRNA export I: dbp5 mutants with defects in RNA binding and ATP hydrolysis define key steps for Nup159 and Gle1.

5. Nup159 Weakens Gle1 Binding to Dbp5 But Does Not Accelerate ADP Release.

6. RNA catalysis as a probe for chaperone activity of DEAD-box helicases.

Review 7. DEAD-box proteins as RNA helicases and chaperones.

Review 8. Nuclear export dynamics of RNA-protein complexes.

9. Nuclear export factor RBM15 facilitates the access of DBP5 to mRNA.

10. Regulation of mRNA export by the PI3 kinase/AKT signal transduction pathway.