OBJECTIVE: We present two patients, a 52-year-old man and a 56-year-old woman, with rapid eye movement sleep behaviour disorder (RBD) since the age of 50. METHOD: In both the patients RBD was videopolysomnographically documented. RESULTS: Both patients developed, with time, autonomic and motor symptoms consistent with the diagnosis of multiple system atrophy. During the course of the disease RBD episodes diminished in frequency but the patients' sleep became even more abnormal, with nearly continuous motor and verbal abnormal behaviours and ambiguous and rapid oscillations of state-determining polysomnographic variables, now consistent with status dissociatus (SD). CONCLUSION: If SD represents the evolution and most extreme form of RBD it should be investigated longitudinally in neurodegenerative diseases.
OBJECTIVE: We present two patients, a 52-year-old man and a 56-year-old woman, with rapid eye movement sleep behaviour disorder (RBD) since the age of 50. METHOD: In both the patients RBD was videopolysomnographically documented. RESULTS: Both patients developed, with time, autonomic and motor symptoms consistent with the diagnosis of multiple system atrophy. During the course of the disease RBD episodes diminished in frequency but the patients' sleep became even more abnormal, with nearly continuous motor and verbal abnormal behaviours and ambiguous and rapid oscillations of state-determining polysomnographic variables, now consistent with status dissociatus (SD). CONCLUSION: If SD represents the evolution and most extreme form of RBD it should be investigated longitudinally in neurodegenerative diseases.
Authors: Jose-Alberto Palma; Clara Fernandez-Cordon; Elizabeth A Coon; Phillip A Low; Mitchell G Miglis; Safwan Jaradeh; Arijit K Bhaumik; Praveen Dayalu; Elena Urrestarazu; Jorge Iriarte; Italo Biaggioni; Horacio Kaufmann Journal: Clin Auton Res Date: 2015-03-05 Impact factor: 4.435
Authors: Pietro-Luca Ratti; Maria Sierra-Peña; Raffaele Manni; Marion Simonetta-Moreau; Julien Bastin; Harrison Mace; Olivier Rascol; Olivier David Journal: PLoS One Date: 2015-03-10 Impact factor: 3.240
Authors: Christopher Wood; Matt Travis Bianchi; Chang-Ho Yun; Chol Shin; Robert Joseph Thomas Journal: Front Physiol Date: 2020-12-03 Impact factor: 4.566