Valérie Cochen De Cock1,2. 1. Pôle sommeil et neurologie, Clinique Beau Soleil, 119 avenue de Lodève, 34070, Montpellier, France. valerie.cochen@gmail.com. 2. EuroMov, University of Montpellier, 700 Avenue du Pic Saint Loup, 34090, Montpellier, France. valerie.cochen@gmail.com.
Abstract
PURPOSE OF REVIEW: The purpose of this review was to explore the different sleep disorders associated with MSA, their mechanisms, and their treatments. RECENT FINDINGS: Stridor is a red flag for the diagnosis of MSA. Recent findings show that its presence in early stage of the disease is associated with a reduction in life expectancy. Its management should be fast and adapted. Its treatment with continuous positive airway pressure or tracheostomy is efficacious. Sleep disorders in MSA are frequent and severe combining insomnia, daytime sleepiness, restless legs syndrome (RLS), REM sleep behavior disorder (RBD), and sleep disordered breathing (SDB). Sleep recordings confirm these disorders. Mechanisms involved in these disorders are complex associating (a) lesions of the pathways regulating sleep and wake or mood but also controlling movement, (b) iatrogenic effects of the treatments, and (3) consequences of the motor or dysautonomic symptoms. RBD prevalence is very high at the beginning of the motor symptoms but then seems to disappear.
PURPOSE OF REVIEW: The purpose of this review was to explore the different sleep disorders associated with MSA, their mechanisms, and their treatments. RECENT FINDINGS: Stridor is a red flag for the diagnosis of MSA. Recent findings show that its presence in early stage of the disease is associated with a reduction in life expectancy. Its management should be fast and adapted. Its treatment with continuous positive airway pressure or tracheostomy is efficacious. Sleep disorders in MSA are frequent and severe combining insomnia, daytime sleepiness, restless legs syndrome (RLS), REM sleep behavior disorder (RBD), and sleep disordered breathing (SDB). Sleep recordings confirm these disorders. Mechanisms involved in these disorders are complex associating (a) lesions of the pathways regulating sleep and wake or mood but also controlling movement, (b) iatrogenic effects of the treatments, and (3) consequences of the motor or dysautonomic symptoms. RBD prevalence is very high at the beginning of the motor symptoms but then seems to disappear.
Entities:
Keywords:
Central sleep apnea syndrome; Insomnia; Multiple system atrophy; Obstructive sleep apnea syndrome; Periodic limb movements; REM sleep behavior disorder; Restless legs syndrome; Sleepiness; Stridor
Authors: Olivier Flabeau; Imad Ghorayeb; Paul Perez; Aline Maillard; Jacques Taillard; Pierre Philip; Alexandra Foubert-Samier; François Tison; Wassilios G Meissner Journal: Parkinsonism Relat Disord Date: 2016-12-16 Impact factor: 4.891
Authors: Sean J Pittock; Timothy Parrett; Charles H Adler; Joseph E Parisi; Dennis W Dickson; J Eric Ahlskog Journal: Mov Disord Date: 2004-06 Impact factor: 10.338
Authors: Roselyne M Rijsman; Louise F Schoolderman; Rob S Rundervoort; Maartje Louter Journal: Parkinsonism Relat Disord Date: 2014-01 Impact factor: 4.891