Literature DB >> 18396163

Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP.

Yoan Chérasse1, Cédric Chaveroux, Céline Jousse, Anne-Catherine Maurin, Valérie Carraro, Laurent Parry, Pierre Fafournoux, Alain Bruhat.   

Abstract

The transcriptional activation of CHOP (C/EBP-homologous protein) by amino acid deprivation involves ATF2 and ATF4 binding at the amino acid response element within the promoter. In this report, we investigate the role of JDP2 (Jun Dimerization Protein 2) in the amino acid control of CHOP transcription following amino acid starvation. Our results show that JDP2 binds to the CHOP AARE in unstimulated cells and that its binding decreases following amino acid starvation. We demonstrate that JDP2 acts as a repressor and suggest that it could be functionally associated with HDAC3 to inhibit CHOP transcription.

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Year:  2008        PMID： 18396163     DOI： 10.1016/j.febslet.2008.03.050

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  12 in total

Review 1.  The transcription factor network associated with the amino acid response in mammalian cells.

Authors:  Michael S Kilberg; Mukundh Balasubramanian; Lingchen Fu; Jixiu Shan
Journal:  Adv Nutr       Date:  2012-05-01       Impact factor: 8.701

2.  Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells.

Authors:  Jixiu Shan; Maria-Cecilia Lopez; Henry V Baker; Michael S Kilberg
Journal:  Physiol Genomics       Date:  2010-03-09       Impact factor: 3.107

3.  Dynamic changes in genomic histone association and modification during activation of the ASNS and ATF3 genes by amino acid limitation.

Authors:  Mukundh N Balasubramanian; Jixiu Shan; Michael S Kilberg
Journal:  Biochem J       Date:  2013-01-01       Impact factor: 3.857

4.  Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress.

Authors:  Sayuri Takayanagi; Riga Fukuda; Yuuki Takeuchi; Sakiko Tsukada; Kenichi Yoshida
Journal:  Cell Stress Chaperones       Date:  2012-07-18       Impact factor: 3.667

5.  The AP-1 repressor protein, JDP2, potentiates hepatocellular carcinoma in mice.

Authors:  Keren Bitton-Worms; Eli Pikarsky; Ami Aronheim
Journal:  Mol Cancer       Date:  2010-03-09       Impact factor: 27.401

6.  JDP2 (Jun Dimerization Protein 2)-deficient mouse embryonic fibroblasts are resistant to replicative senescence.

Authors:  Koji Nakade; Jianzhi Pan; Takahito Yamasaki; Takehide Murata; Bohdan Wasylyk; Kazunari K Yokoyama
Journal:  J Biol Chem       Date:  2009-02-20       Impact factor: 5.157

7.  The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter.

Authors:  Ilona Darlyuk-Saadon; Keren Weidenfeld-Baranboim; Kazunari K Yokoyama; Tsonwin Hai; Ami Aronheim
Journal:  Biochim Biophys Acta       Date:  2012-09-16

8.  Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2.

Authors:  J Pan; K Nakade; Y-C Huang; Z-W Zhu; S Masuzaki; H Hasegawa; T Murata; A Yoshiki; N Yamaguchi; C-H Lee; W-C Yang; E-M Tsai; Y Obata; K K Yokoyama
Journal:  Oncogene       Date:  2010-08-30       Impact factor: 9.867

9.  The ubiquitously expressed bZIP inhibitor, JDP2, suppresses the transcription of its homologue immediate early gene counterpart, ATF3.

Authors:  Keren Weidenfeld-Baranboim; Tal Hasin; Ilona Darlyuk; Ronit Heinrich; Ofer Elhanani; Jianzhi Pan; Kazunari K Yokoyama; Ami Aronheim
Journal:  Nucleic Acids Res       Date:  2009-02-20       Impact factor: 16.971

10.  Activation of alternative Jdp2 promoters and functional protein isoforms in T-cell lymphomas by retroviral insertion mutagenesis.

Authors:  Mads Heilskov Rasmussen; Bruce Wang; Matthias Wabl; Anders Lade Nielsen; Finn Skou Pedersen
Journal:  Nucleic Acids Res       Date:  2009-06-05       Impact factor: 16.971
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