Literature DB >> 18396152

Structure and dynamics of polyunsaturated hydrocarbon chains in lipid bilayers-significance for GPCR function.

Klaus Gawrisch1, Olivier Soubias.   

Abstract

This review summarizes results of our recent solid-state NMR investigations on polyunsaturated 18:0-22:6n3-PC/PE/PS and 18:0-22:5n6-PC bilayers. Data on structure and dynamics of the polyunsaturated docosahexaenoyl (DHAn3, 22:6n3) and docosapentaenoyl chains (DPAn6, 22:5n6), investigated at physiological conditions, are reported. Lipid-protein interaction was studied on reconstituted bilayers containing the G-protein coupled membrane receptor (GPCR) rhodopsin as well as on rod outer segment (ROS) disk membranes prepared from bovine retinas. Results reveal surprisingly rapid conformational transitions of polyunsaturated chains and existence of weakly specific interactions of DHAn3 with spatially distinct sites on rhodopsin.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18396152      PMCID： PMC2453513          DOI： 10.1016/j.chemphyslip.2008.02.016

Source DB:  PubMed          Journal:  Chem Phys Lipids        ISSN： 0009-3084            Impact factor:   3.329


  37 in total

1.  ALTERATION OF THE FATTY ACID COMPOSITION OF BRAIN LIPIDS BY VARYING LEVELS OF DIETARY ESSENTIAL FATTY ACIDS.

Authors:  H MOHRHAUER; R T HOLMAN
Journal:  J Neurochem       Date:  1963-07       Impact factor: 5.372

2.  Relationship of cholesterol content to spatial distribution and age of disc membranes in retinal rod outer segments.

Authors:  K Boesze-Battaglia; S J Fliesler; A D Albert
Journal:  J Biol Chem       Date:  1990-11-05       Impact factor: 5.157

3.  Influence of docosahexaenoic acid and cholesterol on lateral lipid organization in phospholipid mixtures.

Authors:  D Huster; K Arnold; K Gawrisch
Journal:  Biochemistry       Date:  1998-12-08       Impact factor: 3.162

4.  Evidence for a mechanism by which omega-3 polyunsaturated lipids may affect membrane protein function.

Authors:  Mauricio Carrillo-Tripp; Scott E Feller
Journal:  Biochemistry       Date:  2005-08-02       Impact factor: 3.162

5.  Probing specific lipid-protein interaction by saturation transfer difference NMR spectroscopy.

Authors:  Olivier Soubias; Klaus Gawrisch
Journal:  J Am Chem Soc       Date:  2005-09-28       Impact factor: 15.419

6.  Phospholipid fatty acyl spatial distribution in bovine rod outer segment disk membranes.

Authors:  A D Albert; J E Young; Z Paw
Journal:  Biochim Biophys Acta       Date:  1998-01-05

7.  Phosphatidylcholine acyl unsaturation modulates the decrease in interfacial elasticity induced by cholesterol.

Authors:  J M Smaby; M M Momsen; H L Brockman; R E Brown
Journal:  Biophys J       Date:  1997-09       Impact factor: 4.033

8.  2H nuclear magnetic resonance order parameter profiles suggest a change of molecular shape for phosphatidylcholines containing a polyunsaturated acyl chain.

Authors:  L L Holte; S A Peter; T M Sinnwell; K Gawrisch
Journal:  Biophys J       Date:  1995-06       Impact factor: 4.033

9.  Structure of a fluid dioleoylphosphatidylcholine bilayer determined by joint refinement of x-ray and neutron diffraction data. I. Scaling of neutron data and the distributions of double bonds and water.

Authors:  M C Wiener; G I King; S H White
Journal:  Biophys J       Date:  1991-09       Impact factor: 4.033

Review 10.  Computer-based modeling of the conformation and packing properties of docosahexaenoic acid.

Authors:  K R Applegate; J A Glomset
Journal:  J Lipid Res       Date:  1986-06       Impact factor: 5.922
View more
  21 in total

1.  Coupling of retinal, protein, and water dynamics in squid rhodopsin.

Authors:  Eduardo Jardón-Valadez; Ana-Nicoleta Bondar; Douglas J Tobias
Journal:  Biophys J       Date:  2010-10-06       Impact factor: 4.033

2.  All n-3 PUFA are not the same: MD simulations reveal differences in membrane organization for EPA, DHA and DPA.

Authors:  Xiaoling Leng; Jacob J Kinnun; Andres T Cavazos; Samuel W Canner; Saame Raza Shaikh; Scott E Feller; Stephen R Wassall
Journal:  Biochim Biophys Acta Biomembr       Date:  2018-01-03       Impact factor: 3.747

Review 3.  Retinal very long-chain PUFAs: new insights from studies on ELOVL4 protein.

Authors:  Martin-Paul Agbaga; Md Nawajes A Mandal; Robert E Anderson
Journal:  J Lipid Res       Date:  2010-03-18       Impact factor: 5.922

Review 4.  Omega-3 fatty acids, lipid rafts, and T cell signaling.

Authors:  Tim Y Hou; David N McMurray; Robert S Chapkin
Journal:  Eur J Pharmacol       Date:  2015-05-20       Impact factor: 4.432

5.  α-Tocopherol Is Well Designed to Protect Polyunsaturated Phospholipids: MD Simulations.

Authors:  Xiaoling Leng; Jacob J Kinnun; Drew Marquardt; Mikel Ghefli; Norbert Kučerka; John Katsaras; Jeffrey Atkinson; Thad A Harroun; Scott E Feller; Stephen R Wassall
Journal:  Biophys J       Date:  2015-10-20       Impact factor: 4.033

6.  Contribution of membrane elastic energy to rhodopsin function.

Authors:  Olivier Soubias; Walter E Teague; Kirk G Hines; Drake C Mitchell; Klaus Gawrisch
Journal:  Biophys J       Date:  2010-08-04       Impact factor: 4.033

Review 7.  Animal studies of the functional consequences of suboptimal polyunsaturated fatty acid status during pregnancy, lactation and early post-natal life.

Authors:  J Thomas Brenna
Journal:  Matern Child Nutr       Date:  2011-04       Impact factor: 3.092

Review 8.  Omega-3 Fatty Acid and Cardiovascular Outcomes: Insights From Recent Clinical Trials.

Authors:  Xiaoming Jia; Payal Kohli; Salim S Virani
Journal:  Curr Atheroscler Rep       Date:  2019-01-10       Impact factor: 5.113

Review 9.  Models of plasma membrane organization can be applied to mitochondrial membranes to target human health and disease with polyunsaturated fatty acids.

Authors:  Saame Raza Shaikh; David A Brown
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  2012-03-29       Impact factor: 4.006

10.  The Affinity of Cholesterol for Different Phospholipids Affects Lateral Segregation in Bilayers.

Authors:  Oskar Engberg; Victor Hautala; Tomokazu Yasuda; Henrike Dehio; Michio Murata; J Peter Slotte; Thomas K M Nyholm
Journal:  Biophys J       Date:  2016-08-09       Impact factor: 4.033
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.