Literature DB >> 18395206

AR, apoE, and cognitive function.

Jacob Raber1.   

Abstract

Reduced androgen levels in aged men and women might be risk factors for age-related cognitive decline and Alzheimer's disease (AD). Ongoing clinical trials are designed to evaluate the potential benefit of estrogen in women and of testosterone in men. In this review, we discuss the potential beneficial effects of androgens and androgen receptors (ARs) in males and females. In addition, we discuss the hypothesis that AR interacts with apolipoprotein (apoE)4, encoded by epsilon4 and a risk factor for age-related cognitive decline and AD, and the potential consequences of this interaction.

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Year:  2008        PMID： 18395206      PMCID： PMC2409114          DOI： 10.1016/j.yhbeh.2008.02.012

Source DB:  PubMed          Journal:  Horm Behav        ISSN： 0018-506X            Impact factor:   3.587


  121 in total

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Journal:  J Steroid Biochem Mol Biol       Date:  1992-09       Impact factor: 4.292

2.  Memory for spatial locations, motor responses, and objects: triple dissociation among the hippocampus, caudate nucleus, and extrastriate visual cortex.

Authors:  R P Kesner; B L Bolland; M Dakis
Journal:  Exp Brain Res       Date:  1993       Impact factor: 1.972

3.  Testosterone improves maze performance and induces development of a male hippocampus in females.

Authors:  R L Roof; M D Havens
Journal:  Brain Res       Date:  1992-02-14       Impact factor: 3.252

4.  Testosterone influences spatial cognition in older men.

Authors:  J S Janowsky; S K Oviatt; E S Orwoll
Journal:  Behav Neurosci       Date:  1994-04       Impact factor: 1.912

5.  Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro.

Authors:  B P Nathan; S Bellosta; D A Sanan; K H Weisgraber; R W Mahley; R E Pitas
Journal:  Science       Date:  1994-05-06       Impact factor: 47.728

6.  Hormonal regulation of androgen receptor mRNA in the brain and anterior pituitary gland of the male rat.

Authors:  L H Burgess; R J Handa
Journal:  Brain Res Mol Brain Res       Date:  1993-07

7.  Neonatal exogenous testosterone modifies sex difference in radial arm and Morris water maze performance in prepubescent and adult rats.

Authors:  R L Roof
Journal:  Behav Brain Res       Date:  1993-02-26       Impact factor: 3.332

8.  Sex differences and estrous cycle-variations in the AF64A-induced cholinergic deficit in the rat hippocampus.

Authors:  H Hörtnagl; L Hansen; G Kindel; B Schneider; A el Tamer; I Hanin
Journal:  Brain Res Bull       Date:  1993       Impact factor: 4.077

9.  Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats.

Authors:  J Poirier; A Baccichet; D Dea; S Gauthier
Journal:  Neuroscience       Date:  1993-07       Impact factor: 3.590

10.  Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

Authors:  W J Strittmatter; A M Saunders; D Schmechel; M Pericak-Vance; J Enghild; G S Salvesen; A D Roses
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205
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  20 in total

Review 1.  Protective actions of sex steroid hormones in Alzheimer's disease.

Authors:  Christian J Pike; Jenna C Carroll; Emily R Rosario; Anna M Barron
Journal:  Front Neuroendocrinol       Date:  2009-05-07       Impact factor: 8.606

2.  Androgens in health and disease: an overview.

Authors:  Cynthia L Jordan; Lydia Doncarlos
Journal:  Horm Behav       Date:  2008-03-06       Impact factor: 3.587

3.  Translational spatial task and its relationship to HIV-associated neurocognitive disorders and apolipoprotein E in HIV-seropositive women.

Authors:  Diana Morales; Summer F Acevedo; Richard L Skolasky; Rosa Hechavarria; Sharon Santiago; Tania De La Torre; Elizabeth Maldonado; Valerie Wojna
Journal:  J Neurovirol       Date:  2012-09-13       Impact factor: 2.643

4.  Genetic influences on hippocampal volume differ as a function of testosterone level in middle-aged men.

Authors:  Matthew S Panizzon; Richard L Hauger; Lindon J Eaves; Chi-Hua Chen; Anders M Dale; Lisa T Eyler; Bruce Fischl; Christine Fennema-Notestine; Carol E Franz; Michael D Grant; Kristen C Jacobson; Amy J Jak; Michael J Lyons; Sally P Mendoza; Michael C Neale; Elizabeth Prom-Wormley; Larry J Seidman; Ming T Tsuang; Hong Xian; William S Kremen
Journal:  Neuroimage       Date:  2011-10-01       Impact factor: 6.556

5.  Interaction of APOE genotype and testosterone on episodic memory in middle-aged men.

Authors:  Matthew S Panizzon; Richard Hauger; Hong Xian; Eero Vuoksimaa; Kelly M Spoon; Sally P Mendoza; Kristen C Jacobson; Terrie Vasilopoulos; Brinda K Rana; Ruth McKenzie; Jeanne M McCaffery; Michael J Lyons; William S Kremen; Carol E Franz
Journal:  Neurobiol Aging       Date:  2013-12-27       Impact factor: 4.673

6.  Aging and estradiol effects on gene expression in the medial preoptic area, bed nucleus of the stria terminalis, and posterodorsal medial amygdala of male rats.

Authors:  Victoria L Nutsch; Margaret R Bell; Ryan G Will; Weiling Yin; Andrew Wolfe; Ross Gillette; Juan M Dominguez; Andrea C Gore
Journal:  Mol Cell Endocrinol       Date:  2016-12-20       Impact factor: 4.102

Review 7.  Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines.

Authors:  Glenda E Gillies; Simon McArthur
Journal:  Pharmacol Rev       Date:  2010-04-14       Impact factor: 25.468

8.  Gonadal steroids do not affect apolipoprotein E expression in aging mouse cerebral cortex.

Authors:  Sarika Singh; M K Thakur
Journal:  Cell Mol Neurobiol       Date:  2010-12-09       Impact factor: 5.046

9.  3alpha-androstanediol, but not testosterone, attenuates age-related decrements in cognitive, anxiety, and depressive behavior of male rats.

Authors:  Cheryl A Frye; Kassandra L Edinger; Edwin D Lephart; Alicia A Walf
Journal:  Front Aging Neurosci       Date:  2010-04-08       Impact factor: 5.750

Review 10.  Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors.

Authors:  Mariana F Uchoa; V Alexandra Moser; Christian J Pike
Journal:  Front Neuroendocrinol       Date:  2016-09-17       Impact factor: 8.606
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