Literature DB >> 1611529

Testosterone improves maze performance and induces development of a male hippocampus in females.

R L Roof1, M D Havens.   

Abstract

In a combined behavioral and morphometric study, we observed a testosterone-related sexual dimorphism in the granule cell layer of the hippocampus of Sprague-Dawley rats that appears to be related to sex differences in spatial performance. This cell layer was larger and laterally asymmetrical in males. Neonatal testosterone treatment of females resulted in a more male-like hippocampus. These treated females also performed better than controls, and as well as males, on a spatial navigation task. In addition, a strong correlation between the size of granule cell layers and maze performance was detected.

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Year:  1992        PMID： 1611529     DOI： 10.1016/0006-8993(92)90491-q

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  54 in total

1.  Spatial working memory in rats: no differences between the sexes.

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2.  Hippocampal GluR1 associates with behavior in the elevated plus maze and shows sex differences.

Authors:  Xiaojun Xiang; Wen Huang; Colin N Haile; Therese A Kosten
Journal:  Behav Brain Res       Date:  2011-04-07       Impact factor: 3.332

3.  Spatial ability and prenatal androgens: meta-analyses of congenital adrenal hyperplasia and digit ratio (2D:4D) studies.

Authors:  David A Puts; Michael A McDaniel; Cynthia L Jordan; S Marc Breedlove
Journal:  Arch Sex Behav       Date:  2008-02

Review 4.  Sex steroids and the dentate gyrus.

Authors:  Tibor Hajszan; Teresa A Milner; Csaba Leranth
Journal:  Prog Brain Res       Date:  2007       Impact factor: 2.453

5.  Spatiotemporal mapping of sex differences during attentional processing.

Authors:  Andres H Neuhaus; Carolin Opgen-Rhein; Carsten Urbanek; Melanie Gross; Eric Hahn; Thi Minh Tam Ta; Simone Koehler; Michael Dettling
Journal:  Hum Brain Mapp       Date:  2009-09       Impact factor: 5.038

6.  Gender differences and lateralization in the distribution pattern of insulin-like growth factor-1 receptor in developing rat hippocampus: an immunohistochemical study.

Authors:  Javad Hami; Hamed Kheradmand; Hossein Haghir
Journal:  Cell Mol Neurobiol       Date:  2013-11-28       Impact factor: 5.046

7.  Stressful experience has opposite effects on dendritic spines in the hippocampus of cycling versus masculinized females.

Authors:  Christina Dalla; Abigail S Whetstone; Georgia E Hodes; Tracey J Shors
Journal:  Neurosci Lett       Date:  2008-10-22       Impact factor: 3.046

8.  Reversal of long-delay conditioned taste aversion learning in rats by sex hormone manipulation.

Authors:  Michael R Foy; Judith G Foy
Journal:  Integr Physiol Behav Sci       Date:  2003 Jul-Sep

9.  Effects of genistein in the maternal diet on reproductive development and spatial learning in male rats.

Authors:  Evan R Ball; Mary Kay Caniglia; Jenna L Wilcox; Karla A Overton; Marra J Burr; Brady D Wolfe; Brian J Sanders; Amy B Wisniewski; Craige C Wrenn
Journal:  Horm Behav       Date:  2010-01-04       Impact factor: 3.587

10.  Female rats learn trace memories better than male rats and consequently retain a greater proportion of new neurons in their hippocampi.

Authors:  Christina Dalla; Efstathios B Papachristos; Abigail S Whetstone; Tracey J Shors
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-02       Impact factor: 11.205
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