Literature DB >> 18394902

Structure and mode of action of clostridial glucosylating toxins: the ABCD model.

Thomas Jank1, Klaus Aktories.   

Abstract

Toxins A and B, which are the major virulence factors of antibiotic-associated diarrhea and pseudomembranous colitis caused by Clostridium difficile, are the prototypes of the family of clostridial glucosylating toxins. The toxins inactivate Rho and Ras proteins by glucosylation. Recent findings on the autocatalytic processing of the toxins and analysis of the crystal structures of their domains have made a revision of the current model of their actions on the eukaryotic target cells necessary.

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Year:  2008        PMID： 18394902     DOI： 10.1016/j.tim.2008.01.011

Source DB:  PubMed          Journal:  Trends Microbiol        ISSN： 0966-842X            Impact factor:   17.079


  119 in total

1.  Molecular characteristics of Clostridium perfringens TpeL toxin and consequences of mono-O-GlcNAcylation of Ras in living cells.

Authors:  Gregor Guttenberg; Sven Hornei; Thomas Jank; Carsten Schwan; Wei Lü; Oliver Einsle; Panagiotis Papatheodorou; Klaus Aktories
Journal:  J Biol Chem       Date:  2012-06-04       Impact factor: 5.157

2.  Development and evaluation of an ovine antibody-based platform for treatment of Clostridium difficile infection.

Authors:  April Roberts; Joanna McGlashan; Ibrahim Al-Abdulla; Roger Ling; Harriet Denton; Steve Green; Ruth Coxon; John Landon; Clifford Shone
Journal:  Infect Immun       Date:  2011-12-05       Impact factor: 3.441

Review 3.  Allosteric regulation of protease activity by small molecules.

Authors:  Aimee Shen
Journal:  Mol Biosyst       Date:  2010-06-10

4.  Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A.

Authors:  Isa Kreimeyer; Friederike Euler; Alexander Marckscheffel; Helma Tatge; Andreas Pich; Alexandra Olling; Janett Schwarz; Ingo Just; Ralf Gerhard
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-11-03       Impact factor: 3.000

5.  Structural organization of the functional domains of Clostridium difficile toxins A and B.

Authors:  Rory N Pruitt; Melissa G Chambers; Kenneth K-S Ng; Melanie D Ohi; D Borden Lacy
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-12       Impact factor: 11.205

Review 6.  Recent insights into Pasteurella multocida toxin and other G-protein-modulating bacterial toxins.

Authors:  Brenda A Wilson; Mengfei Ho
Journal:  Future Microbiol       Date:  2010-08       Impact factor: 3.165

7.  Development and optimization of a novel assay to measure neutralizing antibodies against Clostridium difficile toxins.

Authors:  Jinfu Xie; Julie Zorman; Lani Indrawati; Melanie Horton; Keri Soring; Joseph M Antonello; Yuhua Zhang; Susan Secore; Matthew Miezeiewski; Su Wang; Anthony D Kanavage; Julie M Skinner; Irene Rogers; Jean-Luc Bodmer; Jon H Heinrichs
Journal:  Clin Vaccine Immunol       Date:  2013-02-06

8.  Clostridium difficile toxin glucosyltransferase domains in complex with a non-hydrolyzable UDP-glucose analogue.

Authors:  Joseph W Alvin; D Borden Lacy
Journal:  J Struct Biol       Date:  2017-04-19       Impact factor: 2.867

Review 9.  Clostridium difficile virulence factors: Insights into an anaerobic spore-forming pathogen.

Authors:  Milena M Awad; Priscilla A Johanesen; Glen P Carter; Edward Rose; Dena Lyras
Journal:  Gut Microbes       Date:  2014

10.  Crystal structure of Clostridium difficile toxin A.

Authors:  Nicole M Chumbler; Stacey A Rutherford; Zhifen Zhang; Melissa A Farrow; John P Lisher; Erik Farquhar; David P Giedroc; Benjamin W Spiller; Roman A Melnyk; D Borden Lacy
Journal:  Nat Microbiol       Date:  2016-01-11       Impact factor: 17.745
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