| Literature DB >> 18394840 |
Tomonori Murakami1, Hidetoshi Konno, Naoto Fukutsu, Michinobu Onodera, Takao Kawasaki, Fumiyo Kusu.
Abstract
An unknown degradation product (DP-1) increased in olmesartan medoxomil (OLM) tablets stored at 40 degrees C/75% r.h., reaching 0.72% after 6 months. The molecular weight and fragment information obtained by LC-MS suggested that DP-1 was a dehydrated dimer of olmesartan (OL) and the presence of ester carbonyl group was indicated by solvent-elimination LC-IR analysis. LC-(1)H NMR confirmed the structure of DP-1 as an esterified dimer of OL. Rapid and accurate identification of the degradation product was achieved by the complementary use of HPLC hyphenated techniques without complicated isolation or purification processes.Entities:
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Year: 2008 PMID： 18394840 DOI： 10.1016/j.jpba.2008.02.021
Source DB: PubMed Journal: J Pharm Biomed Anal ISSN： 0731-7085 Impact factor: 3.935