| Literature DB >> 18393515 |
Dahong Jiang1, Jinsong Peng, Yuanwei Chen.
Abstract
A novel route to the synthesis of Delta2-isoxazoline derivatives is described. Reaction of beta,gamma-unsaturated oximes with aryl bromides via palladium-catalyzed carboetherification affords 3,5-disubstituted Delta2-isoxazolines in good yields. The use of Xantphos as ligand is crucial for the transformation. The carboetherification products can be further converted to beta-hydroxy ketones in the presence of Fe powder and NH4Cl.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18393515 DOI： 10.1021/ol8002173
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005