| Literature DB >> 18393511 |
Kithsiri B Herath1, Chaowei Zhang, Hiranthi Jayasuriya, John G Ondeyka, Deborah L Zink, Bruce Burgess, Jun Wang, Sheo B Singh.
Abstract
Platensimycin and platencin are novel natural product antibiotics that inhibit bacterial growth by inhibiting condensing enzymes FabF and FabF/FabH of fatty acid biosynthesis pathways, respectively. Continued search for the natural congeners of these compounds led to the isolation of platensic acid, the free C-17 tetracyclic enoic acid, and platensimide A, a 2,4-diaminobutyric acid amide derivative. Isolation, structure, semisynthesis, and activity of these compounds are described.Entities:
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Year: 2008 PMID： 18393511 DOI： 10.1021/ol800251v
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005