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Literature DB >> 26617964

Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues.

Kishor L Handore¹, Prakash D Jadhav¹, Bibhabasu Hazra², Anirban Basu², D Srinivasa Reddy¹.

Abstract

The total syntheses of (±)-botryosphaeridione, (±)-pleodendione, (±)-hoaensieremodione, 4-epi-periconianone B, and their analogues have been accomplished for the first time. All the synthesized target compounds were screened in neural anti-inflammatory assays using LPS induced microglia cells (N9). Among them, compounds 1 and 21 were identified as potential lead compounds for further profiling.

Entities: Chemical

Keywords: Natural product; antineuroinflammatory agents; botryosphaeridione; pleodendione; total synthesis

Year: 2015 PMID： 26617964 PMCID： PMC4645243 DOI： 10.1021/acsmedchemlett.5b00241

Source DB: PubMed Journal: ACS Med Chem Lett ISSN： 1948-5875 Impact factor: 4.345

21 in total

1. Total synthesis of colombiasin A and determination of its absolute configuration.

Authors: K C Nicolaou; G Vassilikogiannakis; W Mägerlein; R Kranich
Journal: Chemistry Date: 2001-12-17 Impact factor: 5.236

2. Enantioselective total synthesis of (+)-galbulin via organocatalytic domino Michael-Michael-aldol condensation.

Authors: Bor-Cherng Hong; Che-Sheng Hsu; Gene-Hsiang Lee
Journal: Chem Commun (Camb) Date: 2011-12-16 Impact factor: 6.222

3. Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis.

Authors: Ayan Ghoshal; Sulagna Das; Soumya Ghosh; Manoj Kumar Mishra; Vivek Sharma; Preeti Koli; Ellora Sen; Anirban Basu
Journal: Glia Date: 2007-04-01 Impact factor: 7.452

4. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration.

Authors: Liya Qin; Xuefei Wu; Michelle L Block; Yuxin Liu; George R Breese; Jau-Shyong Hong; Darin J Knapp; Fulton T Crews
Journal: Glia Date: 2007-04-01 Impact factor: 7.452

5. Synthesis of A/B-ring partial analogs of bruceantin as potential antimalarial agents.

Authors: Z Guo; S Vangapandu; A Nimrod; L A Walker; R D Sindelar
Journal: Med Chem Date: 2005-01 Impact factor: 2.745

6. Ready access to functionally embellished cis-hydrindanes and cis-decalins: protecting group-free total syntheses of (±)-Nootkatone and (±)-Noreremophilane.

Authors: Kishor L Handore; B Seetharamsingh; D Srinivasa Reddy
Journal: J Org Chem Date: 2013-07-25 Impact factor: 4.354

Total Syntheses and Biological Evaluation of (±)-Botryosphaeridione, (±)-Pleodendione, 4-epi-Periconianone B, and Analogues.

1. Total synthesis of colombiasin A and determination of its absolute configuration.

2. Enantioselective total synthesis of (+)-galbulin via organocatalytic domino Michael-Michael-aldol condensation.

3. Proinflammatory mediators released by activated microglia induces neuronal death in Japanese encephalitis.

4. Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration.

5. Synthesis of A/B-ring partial analogs of bruceantin as potential antimalarial agents.

6. Ready access to functionally embellished cis-hydrindanes and cis-decalins: protecting group-free total syntheses of (±)-Nootkatone and (±)-Noreremophilane.

7. Platensimycin and platencin congeners from Streptomyces platensis.

8. Tandem Diels-Alder/ene reactions.

9. Krüppel-like factor 4, a novel transcription factor regulates microglial activation and subsequent neuroinflammation.

Review 10. Inflammation in transgenic mouse models of neurodegenerative disorders.

Review 1. Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review.