Literature DB >> 1839027

Comparison of biological and immunochemical properties indicates that scatter factor and hepatocyte growth factor are indistinguishable.

R A Furlong1, T Takehara, W G Taylor, T Nakamura, J S Rubin.   

Abstract

Scatter factor, a stimulant of epithelial cell motility, and Hepatocyte Growth Factor (HGF) were compared by cross-biological studies using naturally occurring and recombinant proteins in four bioassays. Both scatter factor and HGF produced similar effects in cell motility and DNA synthesis assays. Antibodies to scatter factor or HGF neutralized the biological activities of each cytokine, and in immunoblotting reacted with species of the same Mr. These results, together with the available sequence data, suggest that scatter factor and HGF are the same protein.

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Year:  1991        PMID： 1839027     DOI： 10.1242/jcs.100.1.173

Source DB:  PubMed          Journal:  J Cell Sci        ISSN： 0021-9533            Impact factor:   5.285


  24 in total

Review 1.  Control of cell mechanics by RhoA and calcium fluxes during epithelial scattering.

Authors:  Hillary J Haws; Melissa A McNeil; Marc D H Hansen
Journal:  Tissue Barriers       Date:  2016-05-11

Review 2.  Scatter factor/hepatocyte growth factor in brain tumor growth and angiogenesis.

Authors:  Roger Abounader; John Laterra
Journal:  Neuro Oncol       Date:  2005-10       Impact factor: 12.300

Review 3.  Hepatocyte growth factor/scatter factor-induced intracellular signalling.

Authors:  K A Stuart; S M Riordan; S Lidder; L Crostella; R Williams; G G Skouteris
Journal:  Int J Exp Pathol       Date:  2000-02       Impact factor: 1.925

4.  Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice.

Authors:  K Kawaida; K Matsumoto; H Shimazu; T Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

5.  Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium.

Authors:  R J Panos; J S Rubin; K G Csaky; S A Aaronson; R J Mason
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

6.  Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor.

Authors:  S Rong; M Bodescot; D Blair; J Dunn; T Nakamura; K Mizuno; M Park; A Chan; S Aaronson; G F Vande Woude
Journal:  Mol Cell Biol       Date:  1992-11       Impact factor: 4.272

7.  Identification and characterization of "injurin," an inducer of expression of the gene for hepatocyte growth factor.

Authors:  K Matsumoto; H Tajima; M Hamanoue; S Kohno; T Kinoshita; T Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

8.  Effect of scatter factor and hepatocyte growth factor on motility and morphology of MDCK cells.

Authors:  Y Li; A Joseph; M M Bhargava; E M Rosen; T Nakamura; I Goldberg
Journal:  In Vitro Cell Dev Biol       Date:  1992-05

9.  Hepatocyte growth factor and macrophage inflammatory protein 1 beta: structurally distinct cytokines that induce rapid cytoskeletal changes and subset-preferential migration in T cells.

Authors:  D H Adams; L Harvath; D P Bottaro; R Interrante; G Catalano; Y Tanaka; A Strain; S G Hubscher; S Shaw
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-19       Impact factor: 11.205

10.  Effect of hepatocyte growth factor/scatter factor and other growth factors on motility and morphology of non-tumorigenic and tumor cells.

Authors:  Y Li; M M Bhargava; A Joseph; L Jin; E M Rosen; I D Goldberg
Journal:  In Vitro Cell Dev Biol Anim       Date:  1994-02       Impact factor: 2.416
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