Literature DB >> 1534555

Effect of scatter factor and hepatocyte growth factor on motility and morphology of MDCK cells.

Y Li1, A Joseph, M M Bhargava, E M Rosen, T Nakamura, I Goldberg.   

Abstract

We investigated the effects of human placental scatter factor (hSF), mouse scatter factor (mSF) and recombinant human hepatocyte growth factor (HGF) on motility and morphology of individual Madin-Darby canine kidney cells using a computerized cell tracking system. All three factors increased the velocity of individual cells and the ratio of moving to stationary cells. Similarly, all three factors caused changes in morphologic features of cells, leading to increased area, flatness, and polarity. Increases in area and flatness but not polarity were slightly greater with HGF than with hSF or mSF. These results suggest that SFs and HGF have similar effects on motility and morphology of isolated epithelial cells.

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Year:  1992        PMID： 1534555     DOI： 10.1007/bf02877060

Source DB:  PubMed          Journal:  In Vitro Cell Dev Biol        ISSN： 0883-8364


  20 in total

1.  Quantitation of cytokine-stimulated migration of endothelium and epithelium by a new assay using microcarrier beads.

Authors:  E M Rosen; L Meromsky; E Setter; D W Vinter; I D Goldberg
Journal:  Exp Cell Res       Date:  1990-01       Impact factor: 3.905

2.  Measurement of cell motility and morphology with an automated microscope system.

Authors:  G Thurston; B Jaggi; B Palcic
Journal:  Cytometry       Date:  1988-09

3.  Smooth muscle releases an epithelial cell scatter factor which binds to heparin.

Authors:  E M Rosen; I D Goldberg; B M Kacinski; T Buckholz; D W Vinter
Journal:  In Vitro Cell Dev Biol       Date:  1989-02

4.  Human placenta contains an epithelial scatter protein.

Authors:  E M Rosen; L Meromsky; R Romero; E Setter; I Goldberg
Journal:  Biochem Biophys Res Commun       Date:  1990-05-16       Impact factor: 3.575

5.  Purified scatter factor stimulates epithelial and vascular endothelial cell migration.

Authors:  E M Rosen; L Meromsky; E Setter; D W Vinter; I D Goldberg
Journal:  Proc Soc Exp Biol Med       Date:  1990-10

6.  Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.

Authors:  D P Bottaro; J S Rubin; D L Faletto; A M Chan; T E Kmiecik; G F Vande Woude; S A Aaronson
Journal:  Science       Date:  1991-02-15       Impact factor: 47.728

7.  Mechanism of action of the migration stimulating factor produced by fetal and cancer patient fibroblasts: effect on hyaluronic and synthesis.

Authors:  S L Schor; A M Schor; A M Grey; J Chen; G Rushton; M E Grant; I Ellis
Journal:  In Vitro Cell Dev Biol       Date:  1989-08

8.  Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement.

Authors:  E Gherardi; J Gray; M Stoker; M Perryman; R Furlong
Journal:  Proc Natl Acad Sci U S A       Date:  1989-08       Impact factor: 11.205

9.  Studies on the mechanism of scatter factor. Effects of agents that modulate intracellular signal transduction, macromolecule synthesis and cytoskeleton assembly.

Authors:  E M Rosen; L Meromsky; I Goldberg; M Bhargava; E Setter
Journal:  J Cell Sci       Date:  1990-08       Impact factor: 5.285

10.  Comparison of biological and immunochemical properties indicates that scatter factor and hepatocyte growth factor are indistinguishable.

Authors:  R A Furlong; T Takehara; W G Taylor; T Nakamura; J S Rubin
Journal:  J Cell Sci       Date:  1991-09       Impact factor: 5.285
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  8 in total

1.  Detection and characterization of an activity which aligns mesodermal cells into parallel arrays.

Authors:  S F Li; E Klajn; R Marotta; R W Parish
Journal:  J Muscle Res Cell Motil       Date:  1997-04       Impact factor: 2.698

Review 2.  Control of cell mechanics by RhoA and calcium fluxes during epithelial scattering.

Authors:  Hillary J Haws; Melissa A McNeil; Marc D H Hansen
Journal:  Tissue Barriers       Date:  2016-05-11

3.  A mouse model for spatial and temporal expression of HGF in the heart.

Authors:  Ilan Riess; Valentina Sala; Christian Leo; Marco Demaria; Stefano Gatti; Simona Gallo; Amandine Fitou; Ombretta Boero; Renzo Levi; Ivan Cuccovillo; Fabiola Molla; Noeleen De Angelis; Lidia Staszewsky; Roberto Latini; Tiziana Crepaldi
Journal:  Transgenic Res       Date:  2011-03-01       Impact factor: 2.788

Review 4.  Hepatocyte growth factor/scatter factor-induced intracellular signalling.

Authors:  K A Stuart; S M Riordan; S Lidder; L Crostella; R Williams; G G Skouteris
Journal:  Int J Exp Pathol       Date:  2000-02       Impact factor: 1.925

Review 5.  Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe.

Authors:  Michael W Klymkowsky; Pierre Savagner
Journal:  Am J Pathol       Date:  2009-03-26       Impact factor: 4.307

6.  Effect of hepatocyte growth factor/scatter factor and other growth factors on motility and morphology of non-tumorigenic and tumor cells.

Authors:  Y Li; M M Bhargava; A Joseph; L Jin; E M Rosen; I D Goldberg
Journal:  In Vitro Cell Dev Biol Anim       Date:  1994-02       Impact factor: 2.416

7.  Disruption of epithelial cell-matrix interactions induces apoptosis.

Authors:  S M Frisch; H Francis
Journal:  J Cell Biol       Date:  1994-02       Impact factor: 10.539

Review 8.  Bioactive Compounds for the Treatment of Renal Disease.

Authors:  Kang Su Cho; In Kap Ko; James J Yoo
Journal:  Yonsei Med J       Date:  2018-11       Impact factor: 2.759
  8 in total

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