Literature DB >> 18386883

A combined metabolomic and proteomic investigation of the effects of a failure to express dystrophin in the mouse heart.

Melanie K Gulston1, Denis V Rubtsov, Helen J Atherton, Kieran Clarke, Kay E Davies, Kathryn S Lilley, Julian L Griffin.   

Abstract

Muscle degeneration in the heart of 1-9 month-old mdx mice (a model for Duchenne muscular dystrophy) has been monitored using metabolomic and proteomic approaches. In both data sets, a pronounced aging trend was detected in control and mdx mice, and this trend was separate from the disease process. In addition, the characteristic increase in taurine associated with dystrophic tissue is correlated with proteins associated with oxidative phosphorylation and mitochondrial metabolism.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18386883     DOI： 10.1021/pr800070p

Source DB:  PubMed          Journal:  J Proteome Res        ISSN： 1535-3893            Impact factor:   4.466


  18 in total

Review 1.  Metabolomics as a tool for cardiac research.

Authors:  Julian L Griffin; Helen Atherton; John Shockcor; Luigi Atzori
Journal:  Nat Rev Cardiol       Date:  2011-09-20       Impact factor: 32.419

Review 2.  Proteomic profiling of x-linked muscular dystrophy.

Authors:  Caroline Lewis; Steven Carberry; Kay Ohlendieck
Journal:  J Muscle Res Cell Motil       Date:  2009-12       Impact factor: 2.698

3.  Transient receptor potential channel 6 regulates abnormal cardiac S-nitrosylation in Duchenne muscular dystrophy.

Authors:  Heaseung Sophia Chung; Grace E Kim; Ronald J Holewinski; Vidya Venkatraman; Guangshuo Zhu; Djahida Bedja; David A Kass; Jennifer E Van Eyk
Journal:  Proc Natl Acad Sci U S A       Date:  2017-11-29       Impact factor: 11.205

4.  Proteomic Profiling of the Dystrophin-Deficient MDX Heart Reveals Drastically Altered Levels of Key Metabolic and Contractile Proteins.

Authors:  Caroline Lewis; Harald Jockusch; Kay Ohlendieck
Journal:  J Biomed Biotechnol       Date:  2010-05-23

Review 5.  Translational metabolomics in cancer research.

Authors:  Nathaniel W Snyder; Clementina Mesaros; Ian A Blair
Journal:  Biomark Med       Date:  2015-09-01       Impact factor: 2.851

6.  Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate.

Authors:  Marie A Schroeder; Helen J Atherton; Lisa C Heather; Julian L Griffin; Kieran Clarke; George K Radda; Damian J Tyler
Journal:  NMR Biomed       Date:  2011-03-08       Impact factor: 4.044

7.  Proteomics reveals drastic increase of extracellular matrix proteins collagen and dermatopontin in the aged mdx diaphragm model of Duchenne muscular dystrophy.

Authors:  Steven Carberry; Margit Zweyer; Dieter Swandulla; Kay Ohlendieck
Journal:  Int J Mol Med       Date:  2012-05-18       Impact factor: 4.101

8.  Mitochondrial responses to extreme environments: insights from metabolomics.

Authors:  Katie A O'Brien; Julian L Griffin; Andrew J Murray; Lindsay M Edwards
Journal:  Extrem Physiol Med       Date:  2015-05-04

9.  Profiling of age-related changes in the tibialis anterior muscle proteome of the mdx mouse model of dystrophinopathy.

Authors:  Steven Carberry; Margit Zweyer; Dieter Swandulla; Kay Ohlendieck
Journal:  J Biomed Biotechnol       Date:  2012-10-03

10.  Applications of metabolomics and proteomics to the mdx mouse model of Duchenne muscular dystrophy: lessons from downstream of the transcriptome.

Authors:  Julian L Griffin; Christine Des Rosiers
Journal:  Genome Med       Date:  2009-03-25       Impact factor: 11.117
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.