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Literature DB >> 18384647

Permeation of blood-borne IL15 across the blood-brain barrier and the effect of LPS.

Weihong Pan¹, Hung Hsuchou, Chuanhui Yu, Abba J Kastin.

Abstract

Interleukin15 (IL 15) is a proinflammatory cytokine with elevated concentrations in autoimmune diseases involving the periphery (e.g. rheumatoid arthritis) and CNS (e.g. multiple sclerosis). Its interactions with the blood-brain barrier (BBB) were studied in normal and lipopolysaccharide (LPS)-treated mice. (125)I-IL15 remained intact for at least 10 min after i.v. injection and reached CNS parenchyma with regional differences between brain and spinal cord. Both in vivo and in situ brain perfusion of (125)I-IL15 showed that its permeation of the BBB was non-saturable. LPS induced a significant increase of IL15 uptake by the brain and spinal cord, partly related to a higher general permeability of the BBB. The results suggest that the BBB is an interface for blood-borne IL15 to interact with the CNS in the basal state and during inflammation.

Entities: CellLine Chemical Disease Gene Species

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Year: 2008 PMID： 18384647 PMCID： PMC3939609 DOI： 10.1111/j.1471-4159.2008.05390.x

Source DB: PubMed Journal: J Neurochem ISSN： 0022-3042 Impact factor: 5.372

33 in total

Review 1. Interactions of cytokines with the blood-brain barrier: implications for feeding.

Authors: Weihong Pan; Abba J Kastin
Journal: Curr Pharm Des Date: 2003 Impact factor: 3.116

2. Effect of LPS on the permeability of the blood-brain barrier to insulin.

Authors: H Xaio; W A Banks; M L Niehoff; J E Morley
Journal: Brain Res Date: 2001-03-30 Impact factor: 3.252

3. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis.

Authors: I B McInnes; B P Leung; R D Sturrock; M Field; F Y Liew
Journal: Nat Med Date: 1997-02 Impact factor: 53.440

Permeation of blood-borne IL15 across the blood-brain barrier and the effect of LPS.

Review 1. Interactions of cytokines with the blood-brain barrier: implications for feeding.

2. Effect of LPS on the permeability of the blood-brain barrier to insulin.

3. Interleukin-15 mediates T cell-dependent regulation of tumor necrosis factor-alpha production in rheumatoid arthritis.

4. Permeability of the blood-brain and blood-spinal cord barriers to interferons.

5. Differential permeability of the BBB in acute EAE: enhanced transport of TNT-alpha.

6. Interleukin-15 and interleukin-2 enhance non-REM sleep in rabbits.

7. Interleukin-15 gene expression in human astrocytes and microglia in culture.

8. Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

9. Interleukin-2 does not cross the blood-brain barrier by a saturable transport system.

10. The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis.

1. Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis.

2. Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Rα receptor.

3. Interleukin-15 receptor is essential to facilitate GABA transmission and hippocampal-dependent memory.

4. The effects of IL2Rgamma knockout on depression and contextual memory.

5. IL-15 receptor deletion results in circadian changes of locomotor and metabolic activity.

Review 6. Cytokine transport across the injured blood-spinal cord barrier.

7. Cerebral microvascular IL15 is a novel mediator of TNF action.

Review 8. Brain interleukin-15 in neuroinflammation and behavior.

9. Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endothelia.

Review 10. Bench-to-bedside review: Burn-induced cerebral inflammation--a neglected entity?