Literature DB >> 20438766

The effects of IL2Rgamma knockout on depression and contextual memory.

Xiaojun Wu1, Abba J Kastin, Hung Hsuchou, Weihong Pan.   

Abstract

Interleukin (IL)-2Rgamma shows robust upregulation in neuroinflammatory states associated with clinical depression. We tested the hypothesis that mice lacking IL2Rgamma would have decreased depressive-like behavior. Contrary to this expectation, these knockout mice showed increased immobility in both the Porsolt forced swimming and Nomura water wheel tests. By comparison, the auditory fear conditioning test showed increased retention of contextual freezing. Thus, intact IL2Rgamma combats depressive-like behavior. Copyright (c) 2010 Elsevier B.V. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20438766      PMCID： PMC2907353          DOI： 10.1016/j.bbr.2010.04.046

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  28 in total

Review 1.  Contextual fear, gestalt memories, and the hippocampus.

Authors:  M S Fanselow
Journal:  Behav Brain Res       Date:  2000-06-01       Impact factor: 3.332

Review 2.  Neurobiology of Pavlovian fear conditioning.

Authors:  S Maren
Journal:  Annu Rev Neurosci       Date:  2001       Impact factor: 12.449

3.  Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis.

Authors:  Xiaojun Wu; Weihong Pan; Yi He; Hung Hsuchou; Abba J Kastin
Journal:  J Neuroimmunol       Date:  2010-04-28       Impact factor: 3.478

4.  Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

Authors:  R G Phillips; J E LeDoux
Journal:  Behav Neurosci       Date:  1992-04       Impact factor: 1.912

5.  On the sources of strain and sex differences in granule cell number in the dentate area of house mice.

Authors:  C C Wimer; R E Wimer
Journal:  Brain Res Dev Brain Res       Date:  1989-08-01

6.  Tyr-MIF-1 and MIF-1 are active in the water wheel test for antidepressant drugs.

Authors:  A J Kastin; D A Abel; R H Ehrensing; D H Coy; M V Graf
Journal:  Pharmacol Biochem Behav       Date:  1984-11       Impact factor: 3.533

7.  IL-2/15 receptor-beta gene deletion alters neurobehavioral performance.

Authors:  John M Petitto; Zhi Huang; David A Hartemink; Ray Beck
Journal:  Brain Res       Date:  2002-03-08       Impact factor: 3.252

8.  Behavioral despair in mice: a primary screening test for antidepressants.

Authors:  R D Porsolt; A Bertin; M Jalfre
Journal:  Arch Int Pharmacodyn Ther       Date:  1977-10

9.  A new behavioral test for antidepressant drugs.

Authors:  S Nomura; J Shimizu; M Kinjo; H Kametani; T Nakazawa
Journal:  Eur J Pharmacol       Date:  1982-09-24       Impact factor: 4.432

10.  Interleukin 2 receptor gamma chain (gamma(c)) knockout mice show less regularity in estrous cycle but achieve normal pregnancy without fetal compromise.

Authors:  Satomi Miyazaki; Kyoko Tanebe; Masatoshi Sakai; Toshihiko Michimata; Hiroshi Tsuda; Masaki Fujimura; Masataka Nakamura; Yasuo Kiso; Shigeru Saito
Journal:  Am J Reprod Immunol       Date:  2002-04       Impact factor: 3.886
View more
  6 in total

1.  Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Rα receptor.

Authors:  Xiaojun Wu; Hung Hsuchou; Abba J Kastin; Yi He; Reas S Khan; Kirsten P Stone; Michael S Cash; Weihong Pan
Journal:  Psychoneuroendocrinology       Date:  2010-08-17       Impact factor: 4.905

2.  Hypersomnolence and reduced activity in pan-leptin receptor knockout mice.

Authors:  Yuping Wang; Junyun He; Abba J Kastin; Hung Hsuchou; Weihong Pan
Journal:  J Mol Neurosci       Date:  2013-08-18       Impact factor: 3.444

3.  Potential protective role of IL15Rα during inflammation.

Authors:  Weihong Pan; Xiaojun Wu; Abba J Kastin; Yan Zhang; Hung Hsuchou; Franz Halberg; Finla Chatu; Reas S Khan; Barry Robert; Germaine G Cornelissen-Guillaume
Journal:  J Mol Neurosci       Date:  2010-10-28       Impact factor: 3.444

Review 4.  Brain interleukin-15 in neuroinflammation and behavior.

Authors:  Weihong Pan; Xiaojun Wu; Yi He; Hung Hsuchou; Eagle Yi-Kung Huang; Pramod K Mishra; Abba J Kastin
Journal:  Neurosci Biobehav Rev       Date:  2012-11-29       Impact factor: 8.989

5.  Reduced Serum Levels of Soluble Interleukin-15 Receptor α in Schizophrenia and Its Relationship to the Excited Phenotype.

Authors:  Yi He; Qijing Bo; Zhen Mao; Jian Yang; Min Liu; Haixia Wang; Abba J Kastin; Weihong Pan; Chuanyue Wang; Zuoli Sun
Journal:  Front Psychiatry       Date:  2022-03-09       Impact factor: 4.157

6.  Impaired extinction of learned contextual fear memory in early growth response 1 knockout mice.

Authors:  Seungrie Han; Soontaek Hong; Jiwon Mo; Dongmin Lee; Eunju Choi; June-seek Choi; Woong Sun; Hyun Woo Lee; Hyun Kim
Journal:  Mol Cells       Date:  2014-01-27       Impact factor: 5.034
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.