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Literature DB >> 18381586

Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant.

Florian Taft¹, Marco Brünjes, Heinz G Floss, Nadine Czempinski, Stephanie Grond, Florenz Sasse, Andreas Kirschning.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2008 PMID： 18381586 DOI： 10.1002/cbic.200700742

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

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8 in total

1. Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.

Authors: Kirsten Harmrolfs; Marco Brünjes; Gerald Dräger; Heinz G Floss; Florenz Sasse; Florian Taft; Andreas Kirschning
Journal: Chembiochem Date: 2010-12-10 Impact factor: 3.164

2. Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin.

Authors: Simone Eichner; Timo Eichner; Heinz G Floss; Jörg Fohrer; Edgar Hofer; Florenz Sasse; Carsten Zeilinger; Andreas Kirschning
Journal: J Am Chem Soc Date: 2012-01-10 Impact factor: 15.419

3. Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues.

Authors: Martina Werneburg; Benjamin Busch; Jing He; Martin E A Richter; Longkuan Xiang; Bradley S Moore; Martin Roth; Hans-Martin Dahse; Christian Hertweck
Journal: J Am Chem Soc Date: 2010-08-04 Impact factor: 15.419

Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant.

1. Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.

2. Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin.

3. Exploiting enzymatic promiscuity to engineer a focused library of highly selective antifungal and antiproliferative aureothin analogues.

4. Unprecedented deoxygenation at C-7 of the ansamitocin core during mutasynthetic biotransformations.

5. Preparation of new alkyne-modified ansamitocins by mutasynthesis.

Review 6. Cancer wars: natural products strike back.

7. First Ring-Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant.

8. Biosynthetic Plasticity Enables Production of Fluorinated Aurachins.