| Literature DB >> 18378452 |
J Kent Barbay1, Yong Gong, Mieke Buntinx, Jian Li, Concha Claes, Pamela J Hornby, Guy Van Lommen, Jean Van Wauwe, Wei He.
Abstract
A novel series of substituted 2-aryl-5-amino-5,6,7,8-tetrahydroquinoline C5a receptor antagonists is reported. Synthetic routes were developed that allow the substituents on the tetrahydroquinoline core to be efficiently varied, facilitating determination of structure-activity relationships. Members of the series display high binding affinity for the C5a receptor and are potent functional antagonists.Entities:
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Year: 2008 PMID： 18378452 DOI： 10.1016/j.bmcl.2008.03.049
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823