| Literature DB >> 18378447 |
Adrian Hall1, Andy Billinton, Susan H Brown, Anita Chowdhury, Gerard M P Giblin, Paul Goldsmith, David N Hurst, Alan Naylor, Sadhana Patel, Tiziana Scoccitti, Pamela J Theobald.
Abstract
We describe the medicinal chemistry approach that generated a novel indole series of EP(1) receptor antagonists. The SAR of this new template was evaluated and culminated in the identification of compound 12g which demonstrated in vivo efficacy in a preclinical model of inflammatory pain.Entities:
Mesh：
Substances：
Year: 2008 PMID： 18378447 DOI： 10.1016/j.bmcl.2008.03.018
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823