Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 DNA base excision repair activities in mouse models of Alzheimer's disease.

Literature DB >> 18378358

DNA base excision repair activities in mouse models of Alzheimer's disease.

Lior Weissman¹, Nadja C de Souza-Pinto, Mark P Mattson, Vilhelm A Bohr.

Abstract

Alzheimer's disease (AD) has been correlated with elevated levels of oxidative DNA damage. Base excision repair (BER) is the main repair pathway for the removal of oxidative DNA base modifications. We have recently found significant functional deficiencies in BER in brains of sporadic AD and amnestic mild cognitive impairment patients. In this study we tested whether altered BER activities are associated with appearance of symptoms in different brain regions of pre-symptomatic and symptomatic mice harboring mutant APP alone or in combination with Tau and PS1. Our results suggest that unlike in humans, the development of AD-like pathology in the studied mouse models is not associated with deficiencies in BER.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18378358 PMCID： PMC2763940 DOI： 10.1016/j.neurobiolaging.2008.02.014

Source DB: PubMed Journal: Neurobiol Aging ISSN： 0197-4580 Impact factor: 4.673

20 in total

1. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction.

Authors: Salvatore Oddo; Antonella Caccamo; Jason D Shepherd; M Paul Murphy; Todd E Golde; Rakez Kayed; Raju Metherate; Mark P Mattson; Yama Akbari; Frank M LaFerla
Journal: Neuron Date: 2003-07-31 Impact factor: 17.173

2. Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage.

Authors: A Klungland; I Rosewell; S Hollenbach; E Larsen; G Daly; B Epe; E Seeberg; T Lindahl; D E Barnes
Journal: Proc Natl Acad Sci U S A Date: 1999-11-09 Impact factor: 11.205

3. Neonatal lethality with abnormal neurogenesis in mice deficient in DNA polymerase beta.

Authors: N Sugo; Y Aratani; Y Nagashima; Y Kubota; H Koyama
Journal: EMBO J Date: 2000-03-15 Impact factor: 11.598

4. Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.

Authors: N C de Souza-Pinto; L Eide; B A Hogue; T Thybo; T Stevnsner; E Seeberg; A Klungland; V A Bohr
Journal: Cancer Res Date: 2001-07-15 Impact factor: 12.701

5. Expression of 8-oxoguanine DNA glycosylase is reduced and associated with neurofibrillary tangles in Alzheimer's disease brain.

Authors: Takashi Iida; Akiko Furuta; Kenichi Nishioka; Yusaku Nakabeppu; Toru Iwaki
Journal: Acta Neuropathol Date: 2002-01 Impact factor: 17.088

6. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease.

Authors: T Kawarabayashi; L H Younkin; T C Saido; M Shoji; K H Ashe; S G Younkin
Journal: J Neurosci Date: 2001-01-15 Impact factor: 6.167

7. p53 functions in the incorporation step in DNA base excision repair in mouse liver mitochondria.

Authors: Nadja C de Souza-Pinto; Curtis C Harris; Vilhelm A Bohr
Journal: Oncogene Date: 2004-08-26 Impact factor: 9.867

8. Is DNA repair compromised in Alzheimer's disease?

Authors: Vladislav Davydov; Lawrence A Hansen; Deborah A Shackelford
Journal: Neurobiol Aging Date: 2003-11 Impact factor: 4.673

9. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease.

Authors: Salvatore Oddo; Antonella Caccamo; Masashi Kitazawa; Bertrand P Tseng; Frank M LaFerla
Journal: Neurobiol Aging Date: 2003-12 Impact factor: 4.673

10. Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment.

Authors: Lior Weissman; Dong-Gyu Jo; Martin M Sørensen; Nadja C de Souza-Pinto; William R Markesbery; Mark P Mattson; Vilhelm A Bohr
Journal: Nucleic Acids Res Date: 2007-08-17 Impact factor: 16.971

14 in total

Review 1. Genomic integrity and the ageing brain.

Authors: Hei-man Chow; Karl Herrup
Journal: Nat Rev Neurosci Date: 2015-10-14 Impact factor: 34.870

Review 2. The case for rejecting the amyloid cascade hypothesis.

Authors: Karl Herrup
Journal: Nat Neurosci Date: 2015-06 Impact factor: 24.884

3. BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease 1.

Authors: Vilhelm A Bohr; Mark P Mattson; Jenq-Lin Yang; Yu-Ting Lin; Pei-Chin Chuang
Journal: Neuromolecular Med Date: 2013-10-10 Impact factor: 3.843

4. Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.

Authors: Jenq-Lin Yang; Takashi Tadokoro; Guido Keijzers; Mark P Mattson; Vilhelm A Bohr
Journal: J Biol Chem Date: 2010-06-23 Impact factor: 5.157