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Literature DB >> 18375913

PCSK9 function and physiology.

Andrew S Peterson¹, Loren G Fong, Stephen G Young.

Abstract

Entities: Gene

Mesh：

Substances：

Year: 2008 PMID： 18375913 PMCID： PMC2386899 DOI： 10.1194/jlr.E800008-JLR200

Source DB: PubMed Journal: J Lipid Res ISSN： 0022-2275 Impact factor: 5.922

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38 in total

Review 1. The low-density lipoprotein pathway and its relation to atherosclerosis.

Authors: J L Goldstein; M S Brown
Journal: Annu Rev Biochem Date: 1977 Impact factor: 23.643

Review 2. Lipoprotein receptors in the liver. Control signals for plasma cholesterol traffic.

Authors: M S Brown; J L Goldstein
Journal: J Clin Invest Date: 1983-09 Impact factor: 14.808

3. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia.

Authors: Marianne Abifadel; Mathilde Varret; Jean-Pierre Rabès; Delphine Allard; Khadija Ouguerram; Martine Devillers; Corinne Cruaud; Suzanne Benjannet; Louise Wickham; Danièle Erlich; Aurélie Derré; Ludovic Villéger; Michel Farnier; Isabel Beucler; Eric Bruckert; Jean Chambaz; Bernard Chanu; Jean-Michel Lecerf; Gerald Luc; Philippe Moulin; Jean Weissenbach; Annick Prat; Michel Krempf; Claudine Junien; Nabil G Seidah; Catherine Boileau
Journal: Nat Genet Date: 2003-06 Impact factor: 38.330

4. Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype.

Authors: Kara N Maxwell; Jan L Breslow
Journal: Proc Natl Acad Sci U S A Date: 2004-04-26 Impact factor: 11.205

5. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol.

Authors: Suzanne Benjannet; David Rhainds; Rachid Essalmani; Janice Mayne; Louise Wickham; Weijun Jin; Marie-Claude Asselin; Josée Hamelin; Mathilde Varret; Delphine Allard; Mélanie Trillard; Marianne Abifadel; Angie Tebon; Alan D Attie; Daniel J Rader; Catherine Boileau; Louise Brissette; Michel Chrétien; Annik Prat; Nabil G Seidah
Journal: J Biol Chem Date: 2004-09-09 Impact factor: 5.157

6. Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice.

Authors: Kara N Maxwell; Raymond E Soccio; Elizabeth M Duncan; Ephraim Sehayek; Jan L Breslow
Journal: J Lipid Res Date: 2003-08-01 Impact factor: 5.922

7. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation.

Authors: Nabil G Seidah; Suzanne Benjannet; Louise Wickham; Jadwiga Marcinkiewicz; Stephanie Belanger Jasmin; Stefano Stifani; Ajoy Basak; Annik Prat; Michel Chretien
Journal: Proc Natl Acad Sci U S A Date: 2003-01-27 Impact factor: 11.205

8. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.

Authors: Geneviève Dubuc; Ann Chamberland; Hanny Wassef; Jean Davignon; Nabil G Seidah; Lise Bernier; Annik Prat
Journal: Arterioscler Thromb Vasc Biol Date: 2004-06-03 Impact factor: 8.311

9. Deletion of two growth-factor repeats from the low-density-lipoprotein receptor accelerates its degradation.

Authors: D R van der Westhuyzen; M L Stein; H E Henderson; A D Marais; A M Fourie; G A Coetzee
Journal: Biochem J Date: 1991-08-01 Impact factor: 3.857

10. Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region.

Authors: C G Davis; J L Goldstein; T C Südhof; R G Anderson; D W Russell; M S Brown
Journal: Nature Date: 1987 Apr 23-29 Impact factor: 49.962

14 in total

1. PCSK9 - A New and Potent Approach to Lowering Cholesterol.

Authors: Thomas F Whayne
Journal: Oman Med J Date: 2013-05

2. Modeling and Simulation to Support Phase 2 Dose Selection for RG7652, a Fully Human Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9.

Authors: Nageshwar R Budha; Maya Leabman; Jin Y Jin; D Russell Wada; Amos Baruch; Kun Peng; Whittemore G Tingley; John D Davis
Journal: AAPS J Date: 2015-03-31 Impact factor: 4.009

3. Combined PCSK9 and APOE polymorphisms are genetic risk factors associated with elevated plasma lipid levels in a Thai population.

Authors: Nutjaree Jeenduang; Sureerut Porntadavity; Smith Wanmasae
Journal: Lipids Date: 2015-04-22 Impact factor: 1.880

4. PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.

Authors: Marie W Lindholm; Joacim Elmén; Niels Fisker; Henrik F Hansen; Robert Persson; Marianne R Møller; Christoph Rosenbohm; Henrik Ørum; Ellen M Straarup; Troels Koch
Journal: Mol Ther Date: 2011-11-22 Impact factor: 11.454

5. Relation between proprotein convertase subtilisin/kexin type 9 and directly measured low-density lipoprotein cholesterol.

Authors: Kristen M Tecson; Katherine S Panettiere-Kennedy; Jane I Won; Puja Garg; Oluseun Olugbode; Peter A McCullough
Journal: Proc (Bayl Univ Med Cent) Date: 2017-01

Review 6. Promises and challenges of pharmacogenetics: an overview of study design, methodological and statistical issues.

Authors: Stephanie Ross; Sonia S Anand; Philip Joseph; Guillaume Paré
Journal: JRSM Cardiovasc Dis Date: 2012-04-05

7. Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes.

Authors: Julia K Goodrich; Moriel Singer-Berk; Rachel Son; Abigail Sveden; Jordan Wood; Eleina England; Joanne B Cole; Ben Weisburd; Nick Watts; Lizz Caulkins; Peter Dornbos; Ryan Koesterer; Zachary Zappala; Haichen Zhang; Kristin A Maloney; Andy Dahl; Carlos A Aguilar-Salinas; Gil Atzmon; Francisco Barajas-Olmos; Nir Barzilai; John Blangero; Eric Boerwinkle; Lori L Bonnycastle; Erwin Bottinger; Donald W Bowden; Federico Centeno-Cruz; John C Chambers; Nathalie Chami; Edmund Chan; Juliana Chan; Ching-Yu Cheng; Yoon Shin Cho; Cecilia Contreras-Cubas; Emilio Córdova; Adolfo Correa; Ralph A DeFronzo; Ravindranath Duggirala; Josée Dupuis; Ma Eugenia Garay-Sevilla; Humberto García-Ortiz; Christian Gieger; Benjamin Glaser; Clicerio González-Villalpando; Ma Elena Gonzalez; Niels Grarup; Leif Groop; Myron Gross; Christopher Haiman; Sohee Han; Craig L Hanis; Torben Hansen; Nancy L Heard-Costa; Brian E Henderson; Juan Manuel Malacara Hernandez; Mi Yeong Hwang; Sergio Islas-Andrade; Marit E Jørgensen; Hyun Min Kang; Bong-Jo Kim; Young Jin Kim; Heikki A Koistinen; Jaspal Singh Kooner; Johanna Kuusisto; Soo-Heon Kwak; Markku Laakso; Leslie Lange; Jong-Young Lee; Juyoung Lee; Donna M Lehman; Allan Linneberg; Jianjun Liu; Ruth J F Loos; Valeriya Lyssenko; Ronald C W Ma; Angélica Martínez-Hernández; James B Meigs; Thomas Meitinger; Elvia Mendoza-Caamal; Karen L Mohlke; Andrew D Morris; Alanna C Morrison; Maggie C Y Ng; Peter M Nilsson; Christopher J O'Donnell; Lorena Orozco; Colin N A Palmer; Kyong Soo Park; Wendy S Post; Oluf Pedersen; Michael Preuss; Bruce M Psaty; Alexander P Reiner; Cristina Revilla-Monsalve; Stephen S Rich; Jerome I Rotter; Danish Saleheen; Claudia Schurmann; Xueling Sim; Rob Sladek; Kerrin S Small; Wing Yee So; Timothy D Spector; Konstantin Strauch; Tim M Strom; E Shyong Tai; Claudia H T Tam; Yik Ying Teo; Farook Thameem; Brian Tomlinson; Russell P Tracy; Tiinamaija Tuomi; Jaakko Tuomilehto; Teresa Tusié-Luna; Rob M van Dam; Ramachandran S Vasan; James G Wilson; Daniel R Witte; Tien-Yin Wong; Noël P Burtt; Noah Zaitlen; Mark I McCarthy; Michael Boehnke; Toni I Pollin; Jason Flannick; Josep M Mercader; Anne O'Donnell-Luria; Samantha Baxter; Jose C Florez; Daniel G MacArthur; Miriam S Udler
Journal: Nat Commun Date: 2021-06-09 Impact factor: 17.694