Literature DB >> 18374566

2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis.

Lalgudi S Harikrishnan1, Muthoni G Kamau, Timothy F Herpin, George C Morton, Yalei Liu, Christopher B Cooper, Mark E Salvati, Jennifer X Qiao, Tammy C Wang, Leonard P Adam, David S Taylor, Alice Ye A Chen, Xiaohong Yin, Ramakrishna Seethala, Tara L Peterson, David S Nirschl, Arthur V Miller, Carolyn A Weigelt, Kingsley K Appiah, Jonathan C O'Connell, R Michael Lawrence.   

Abstract

2-Arylbenzoxazole 5 was identified as a hit from a fluorescence-based high-throughput screen for CETP inhibitors. The synthesis and SAR investigation employing array synthesis of the A- and B-rings are described.

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Year:  2008        PMID: 18374566     DOI: 10.1016/j.bmcl.2008.03.030

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

1.  An Aggregation Advisor for Ligand Discovery.

Authors:  John J Irwin; Da Duan; Hayarpi Torosyan; Allison K Doak; Kristin T Ziebart; Teague Sterling; Gurgen Tumanian; Brian K Shoichet
Journal:  J Med Chem       Date:  2015-08-28       Impact factor: 7.446

Review 2.  The role of ligand efficiency metrics in drug discovery.

Authors:  Andrew L Hopkins; György M Keserü; Paul D Leeson; David C Rees; Charles H Reynolds
Journal:  Nat Rev Drug Discov       Date:  2014-02       Impact factor: 84.694

3.  Ethyl 3-nitro-4-(propyl-amino)benzoate.

Authors:  Siti Marina Mohd Maidin; Aisyah Saad Abdul Rahim; Shafida Abdul Hamid; Reza Kia; Hoong-Kun Fun
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-07-16
  3 in total

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