OBJECTIVE: To assess clinical determinants of systemic inflammation in persons with chronic spinal cord injury (SCI). DESIGN: Cross-sectional survey. SETTING: Veterans Affairs medical center. PARTICIPANTS: As part of an epidemiologic study assessing SCI-related health conditions, 63 men with chronic SCI provided a blood sample and information regarding locomotive mode and personal habits. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE: Plasma high-sensitivity C-reactive protein (CRP). RESULTS: The mean +/- standard deviation age was 56+/-14y, and participants were assessed 21+/-13y after injury. Adjusting for heart disease, hypertension, and body mass index (BMI), the mean CRP in 12 motorized wheelchair users (5.11mg/L) was not significantly greater than 23 participants who used a manual wheelchair (2.19mg/L) (P=.085) but was significantly greater than the 17 who walked with an assistive device (1.41mg/L) (P=.005) and the 12 who walked independently (1.63mg/L) (P=.027). CRP was significantly greater in participants with obesity but was not related to age, smoking, or SCI level and severity. CRP was elevated in participants reporting a urinary tract infection (UTI) or pressure ulcer within a year, but adjustment for this did not account for the elevated CRP in motorized wheelchair users. CONCLUSIONS: These results suggest that CRP in chronic SCI is independently related to locomotive mode, BMI, and a history of pressure ulcers and UTI. It is suggested that future studies in SCI investigate whether modifying these factors influence systemic inflammation and cardiovascular health.
OBJECTIVE: To assess clinical determinants of systemic inflammation in persons with chronic spinal cord injury (SCI). DESIGN: Cross-sectional survey. SETTING: Veterans Affairs medical center. PARTICIPANTS: As part of an epidemiologic study assessing SCI-related health conditions, 63 men with chronic SCI provided a blood sample and information regarding locomotive mode and personal habits. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURE: Plasma high-sensitivity C-reactive protein (CRP). RESULTS: The mean +/- standard deviation age was 56+/-14y, and participants were assessed 21+/-13y after injury. Adjusting for heart disease, hypertension, and body mass index (BMI), the mean CRP in 12 motorized wheelchair users (5.11mg/L) was not significantly greater than 23 participants who used a manual wheelchair (2.19mg/L) (P=.085) but was significantly greater than the 17 who walked with an assistive device (1.41mg/L) (P=.005) and the 12 who walked independently (1.63mg/L) (P=.027). CRP was significantly greater in participants with obesity but was not related to age, smoking, or SCI level and severity. CRP was elevated in participants reporting a urinary tract infection (UTI) or pressure ulcer within a year, but adjustment for this did not account for the elevated CRP in motorized wheelchair users. CONCLUSIONS: These results suggest that CRP in chronic SCI is independently related to locomotive mode, BMI, and a history of pressure ulcers and UTI. It is suggested that future studies in SCI investigate whether modifying these factors influence systemic inflammation and cardiovascular health.
Authors: Howard D Sesso; Julie E Buring; Nader Rifai; Gavin J Blake; J Michael Gaziano; Paul M Ridker Journal: JAMA Date: 2003-12-10 Impact factor: 56.272
Authors: Kimberly M Anderson; C Jane Welsh; Colin Young; Gwendolyn J Levine; Sharon C Kerwin; C Elizabeth Boudreau; Ismael Reyes; Armando Mondragon; John F Griffin; Noah D Cohen; Jonathan M Levine Journal: J Neurotrauma Date: 2015-07-17 Impact factor: 5.269
Authors: James S Krause; Nicole D DiPiro; Lee L Saunders; Susan D Newman; Narendra L Banik; Sookyoung Park Journal: Top Spinal Cord Inj Rehabil Date: 2014