Literature DB >> 18373984

Polymorphism of human telomeric quadruplex structures.

Jixun Dai1, Megan Carver, Danzhou Yang.   

Abstract

Human telomeric DNA consists of tandem repeats of the sequence d(TTAGGG). Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the human telomeric sequence have been shown to inhibit the activity of telomerase and telomere maintenance, thus the telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. Knowledge of intramolecular human telomeric G-quadruplex structure(s) formed under physiological conditions is important for structure-based rational drug design and thus has been the subject of intense investigation. This review will give an overview of recent progress on the intramolecular human telomeric G-quadruplex structures formed in K+ solution. It will also give insight into the structure polymorphism of human telomeric sequences and its implications for drug targeting.

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Year:  2008        PMID： 18373984      PMCID： PMC2556180          DOI： 10.1016/j.biochi.2008.02.026

Source DB:  PubMed          Journal:  Biochimie        ISSN： 0300-9084            Impact factor:   4.079


  77 in total

Review 1.  Drug targeting of the c-MYC promoter to repress gene expression via a G-quadruplex silencer element.

Authors:  Laurence H Hurley; Daniel D Von Hoff; Adam Siddiqui-Jain; Danzhou Yang
Journal:  Semin Oncol       Date:  2006-08       Impact factor: 4.929

2.  Effect of ions on the polymorphism, effective charge, and stability of human telomeric DNA. Photon correlation spectroscopy and circular dichroism studies.

Authors:  Agnieszka Włodarczyk; Przemysław Grzybowski; Adam Patkowski; Andrzej Dobek
Journal:  J Phys Chem B       Date:  2005-03-03       Impact factor: 2.991

3.  Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold.

Authors:  Kim Ngoc Luu; Anh Tuân Phan; Vitaly Kuryavyi; Laurent Lacroix; Dinshaw J Patel
Journal:  J Am Chem Soc       Date:  2006-08-02       Impact factor: 15.419

4.  The new models of the human telomere d[AGGG(TTAGGG)3] in K+ solution.

Authors:  Yan Xu; Yuki Noguchi; Hiroshi Sugiyama
Journal:  Bioorg Med Chem       Date:  2006-05-08       Impact factor: 3.641

5.  An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution.

Authors:  Jixun Dai; Thomas S Dexheimer; Ding Chen; Megan Carver; Attila Ambrus; Roger A Jones; Danzhou Yang
Journal:  J Am Chem Soc       Date:  2006-02-01       Impact factor: 15.419

6.  Extreme conformational diversity in human telomeric DNA.

Authors:  J Y Lee; Burak Okumus; D S Kim; Taekjip Ha
Journal:  Proc Natl Acad Sci U S A       Date:  2005-12-19       Impact factor: 11.205

7.  Evidence for the presence of a guanine quadruplex forming region within a polypurine tract of the hypoxia inducible factor 1alpha promoter.

Authors:  Richard De Armond; Stacey Wood; Daekyu Sun; Laurence H Hurley; Scot W Ebbinghaus
Journal:  Biochemistry       Date:  2005-12-13       Impact factor: 3.162

8.  Facilitation of a structural transition in the polypurine/polypyrimidine tract within the proximal promoter region of the human VEGF gene by the presence of potassium and G-quadruplex-interactive agents.

Authors:  Daekyu Sun; Kexiao Guo; Jadrian J Rusche; Laurence H Hurley
Journal:  Nucleic Acids Res       Date:  2005-10-20       Impact factor: 16.971

9.  Guanine tetraplex topology of human telomere DNA is governed by the number of (TTAGGG) repeats.

Authors:  Michaela Vorlícková; Jana Chládková; Iva Kejnovská; Markéta Fialová; Jaroslav Kypr
Journal:  Nucleic Acids Res       Date:  2005-10-12       Impact factor: 16.971

10.  Human telomeric sequence forms a hybrid-type intramolecular G-quadruplex structure with mixed parallel/antiparallel strands in potassium solution.

Authors:  Attila Ambrus; Ding Chen; Jixun Dai; Tiffanie Bialis; Roger A Jones; Danzhou Yang
Journal:  Nucleic Acids Res       Date:  2006-05-19       Impact factor: 16.971
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  114 in total

1.  Resolution of quadruplex polymorphism by size-exclusion chromatography.

Authors:  M Clarke Miller; John O Trent
Journal:  Curr Protoc Nucleic Acid Chem       Date:  2011-06

2.  Polymorphism and resolution of oncogene promoter quadruplex-forming sequences.

Authors:  M Clarke Miller; Huy T Le; William L Dean; Patrick A Holt; Jonathan B Chaires; John O Trent
Journal:  Org Biomol Chem       Date:  2011-09-21       Impact factor: 3.876

3.  Heterocyclic dications as a new class of telomeric G-quadruplex targeting agents.

Authors:  Rupesh Nanjunda; Caterina Musetti; Arvind Kumar; Mohamed A Ismail; Abdelbasset A Farahat; Siming Wang; Claudia Sissi; Manlio Palumbo; David W Boykin; W David Wilson
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

4.  Human AP-endonuclease (Ape1) activity on telomeric G4 structures is modulated by acetylatable lysine residues in the N-terminal sequence.

Authors:  Silvia Burra; Daniela Marasco; Matilde Clarissa Malfatti; Giulia Antoniali; Antonella Virgilio; Veronica Esposito; Bruce Demple; Aldo Galeone; Gianluca Tell
Journal:  DNA Repair (Amst)       Date:  2018-11-22

5.  Molecular Recognition of the Hybrid-2 Human Telomeric G-Quadruplex by Epiberberine: Insights into Conversion of Telomeric G-Quadruplex Structures.

Authors:  Clement Lin; Guanhui Wu; Kaibo Wang; Buket Onel; Saburo Sakai; Yong Shao; Danzhou Yang
Journal:  Angew Chem Int Ed Engl       Date:  2018-07-18       Impact factor: 15.336

6.  Photocrosslinking of human telomeric G-quadruplex loops by anti cyclobutane thymine dimer formation.

Authors:  Dian G T Su; Huafeng Fang; Michael L Gross; John-Stephen A Taylor
Journal:  Proc Natl Acad Sci U S A       Date:  2009-07-23       Impact factor: 11.205

7.  2-aminopurine as a probe for quadruplex loop structures.

Authors:  Robert D Gray; Luigi Petraccone; Robert Buscaglia; Jonathan B Chaires
Journal:  Methods Mol Biol       Date:  2010

Review 8.  Human telomeric G-quadruplex: thermodynamic and kinetic studies of telomeric quadruplex stability.

Authors:  Jonathan B Chaires
Journal:  FEBS J       Date:  2009-11-27       Impact factor: 5.542

9.  Characterization of a K+-induced conformational switch in a human telomeric DNA oligonucleotide using 2-aminopurine fluorescence.

Authors:  Robert D Gray; Luigi Petraccone; John O Trent; Jonathan B Chaires
Journal:  Biochemistry       Date:  2010-01-12       Impact factor: 3.162

10.  Folding dynamics and conformational heterogeneity of human telomeric G-quadruplex structures in Na+ solutions by single molecule FRET microscopy.

Authors:  Sofie L Noer; Søren Preus; Daniel Gudnason; Mikayel Aznauryan; Jean-Louis Mergny; Victoria Birkedal
Journal:  Nucleic Acids Res       Date:  2015-11-28       Impact factor: 16.971
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