| Literature DB >> 18371314 |
Olivia S Rissland1, Chris J Norbury.
Abstract
The Schizosaccharomyces pombe cytoplasmic protein Cid1 acts as a poly(U) polymerase (PUP). Polyadenylated actin mRNA, a target of this activity, is uridylated upon arrest in S phase and is likely to be one of many such Cid1 targets. This RNA uridylation pathway appears to be conserved, as Cid1 orthologs in Arabidopsis thaliana, Caenorhabditis elegans and humans display PUP activity either in vitro or in Xenopus laevis oocytes. Here, we review the literature on Cid1, other PUPs and uridylation, a conserved and previously under-appreciated mechanism of RNA regulation.Entities:
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Year: 2008 PMID： 18371314 DOI： 10.1016/j.bbagrm.2008.03.003
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002