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Literature DB >> 18370213

Electroporation for drug and gene delivery in the clinic: doctors go electric.

Abstract

Electroporation is a unique system for drug and gene delivery, as it is possible to very specifically target certain tissues within the body with whatever drug, gene, isotope, or other product is desired in a specific situation. An increasing number of clinical trials are being launched, and sophistication of equipment and protocols continues. This chapter reviews present knowledge from clinical trials, describes important issues in the patient management when using electroporation, and outlines future perspectives of the technology.

Entities: Species

Mesh：

Substances：
DNA, Recombinant

Year: 2008 PMID： 18370213 DOI： 10.1007/978-1-59745-194-9_27

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

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Cited

20 in total

1. Nanoelectroablation therapy for murine basal cell carcinoma.

Authors: Richard Nuccitelli; Saleh Sheikh; Kevin Tran; Brian Athos; Mark Kreis; Pamela Nuccitelli; Kris S Chang; Ervin H Epstein; Jean Y Tang
Journal: Biochem Biophys Res Commun Date: 2012-07-04 Impact factor: 3.575

Review 2. What is (still not) known of the mechanism by which electroporation mediates gene transfer and expression in cells and tissues.

Authors: Jean-Michel Escoffre; Thomas Portet; Luc Wasungu; Justin Teissié; David Dean; Marie-Pierre Rols
Journal: Mol Biotechnol Date: 2008-11-18 Impact factor: 2.695

3. Contactless magneto-permeabilization for intracellular plasmid DNA delivery in-vivo.

Authors: Thomas J Kardos; Dietmar P Rabussay
Journal: Hum Vaccin Immunother Date: 2012-08-16 Impact factor: 3.452

4. Changes in optical properties of electroporated cells as revealed by digital holographic microscopy.

Authors: Violeta L Calin; Mona Mihailescu; Nicolae Mihale; Alexandra V Baluta; Eugenia Kovacs; Tudor Savopol; Mihaela G Moisescu
Journal: Biomed Opt Express Date: 2017-03-16 Impact factor: 3.732

Review 5. Gene electrotransfer: from biophysical mechanisms to in vivo applications : Part 2 - In vivo developments and present clinical applications.

Authors: Jean-Michel Escoffre; Chloé Mauroy; Thomas Portet; Luc Wasungu; Aurelie Paganin-Gioanni; Muriel Golzio; Justin Teissié; Marie-Pierre Rols
Journal: Biophys Rev Date: 2009-11-10

6. Biological properties of melanoma and endothelial cells after plasmid AMEP gene electrotransfer depend on integrin quantity on cells.

Authors: Masa Bosnjak; Lara Prosen; Tanja Dolinsek; Tanja Blagus; Bostjan Markelc; Maja Cemazar; Celine Bouquet; Gregor Sersa
Journal: J Membr Biol Date: 2013-05-07 Impact factor: 1.843

Electroporation for drug and gene delivery in the clinic: doctors go electric.

1. Nanoelectroablation therapy for murine basal cell carcinoma.

Review 2. What is (still not) known of the mechanism by which electroporation mediates gene transfer and expression in cells and tissues.

3. Contactless magneto-permeabilization for intracellular plasmid DNA delivery in-vivo.

4. Changes in optical properties of electroporated cells as revealed by digital holographic microscopy.

Review 5. Gene electrotransfer: from biophysical mechanisms to in vivo applications : Part 2 - In vivo developments and present clinical applications.

6. Biological properties of melanoma and endothelial cells after plasmid AMEP gene electrotransfer depend on integrin quantity on cells.

7. APOBEC3A intratumoral DNA electroporation in mice.

Review 8. Microscale electroporation: challenges and perspectives for clinical applications.

9. Numerical optimization of gene electrotransfer into muscle tissue.

10. Nanoelectroablation of human pancreatic carcinoma in a murine xenograft model without recurrence.