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Literature DB >> 18370145

ENU mutagenesis in mice.

Philippe Georgel¹, Xin Du, Kasper Hoebe, Bruce Beutler.

Abstract

Forward genetics has led to many "breakthrough" discoveries, and with the mouse genome almost fully sequenced, the creation of phenotypes through random germline mutagenesis has become an efficient means by which to find the function of yet undescribed genes. In this chapter, we will provide a practical guideline for performing germline mutagenesis in mice. In particular, we will focus on the application of this technology to identify genes that are essential to innate immune defense.

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Year: 2008 PMID： 18370145 DOI： 10.1007/978-1-59745-570-1_1

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

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Cited

36 in total

1. iRhom2 is required for the secretion of mouse TNFα.

Authors: Owen M Siggs; Nengming Xiao; Ying Wang; Hexin Shi; Wataru Tomisato; Xiaohong Li; Yu Xia; Bruce Beutler
Journal: Blood Date: 2012-05-01 Impact factor: 22.113

2. Real-time resolution of point mutations that cause phenovariance in mice.

Authors: Tao Wang; Xiaowei Zhan; Chun-Hui Bu; Stephen Lyon; David Pratt; Sara Hildebrand; Jin Huk Choi; Zhao Zhang; Ming Zeng; Kuan-wen Wang; Emre Turer; Zhe Chen; Duanwu Zhang; Tao Yue; Ying Wang; Hexin Shi; Jianhui Wang; Lei Sun; Jeff SoRelle; William McAlpine; Noelle Hutchins; Xiaoming Zhan; Maggy Fina; Rochelle Gobert; Jiexia Quan; McKensie Kreutzer; Stephanie Arnett; Kimberly Hawkins; Ashley Leach; Christopher Tate; Chad Daniel; Carlos Reyna; Lauren Prince; Sheila Davis; Joel Purrington; Rick Bearden; Jennifer Weatherly; Danielle White; Jamie Russell; Qihua Sun; Miao Tang; Xiaohong Li; Lindsay Scott; Eva Marie Y Moresco; Gerald M McInerney; Gunilla B Karlsson Hedestam; Yang Xie; Bruce Beutler
Journal: Proc Natl Acad Sci U S A Date: 2015-01-20 Impact factor: 11.205

3. IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.

Authors: Jin Huk Choi; Kuan-Wen Wang; Duanwu Zhang; Xiaowei Zhan; Tao Wang; Chun-Hui Bu; Cassie L Behrendt; Ming Zeng; Ying Wang; Takuma Misawa; Xiaohong Li; Miao Tang; Xiaoming Zhan; Lindsay Scott; Sara Hildebrand; Anne R Murray; Eva Marie Y Moresco; Lora V Hooper; Bruce Beutler
Journal: Proc Natl Acad Sci U S A Date: 2017-01-30 Impact factor: 11.205

ENU mutagenesis in mice.

1. iRhom2 is required for the secretion of mouse TNFα.

2. Real-time resolution of point mutations that cause phenovariance in mice.

3. IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.

Review 4. Going forward with genetics: recent technological advances and forward genetics in mice.

Review 5. Mouse models in male fertility research.

Review 6. Innate immunity and the new forward genetics.

7. Increased susceptibility to DNA virus infection in mice with a GCN2 mutation.

8. Creatine maintains intestinal homeostasis and protects against colitis.

9. Gab3 is required for IL-2- and IL-15-induced NK cell expansion and limits trophoblast invasion during pregnancy.

10. New genetic resources for mammalian developmental biologists.